Coenzyme Q10 attenuated β-amyloid25–35 –induced inflammatory responses in PC12 cells through regulation of the NF–κB signaling pathway

Highlights • CoQ10 showed neuroprotective effects in Aβ25–35 –induced PC12 cells. • CoQ10 attenuated neuroinflammatory responses. • CoQ10 inactivated NF–κB dependent inflammatory pathways.

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Bibliographic Details
Published in:Brain research bulletin 2017-05, Vol.131, p.192-198
Main Authors: Li, Li, Xu, Daohua, Lin, Jiantao, Zhang, Dawei, Wang, Guanhai, Sui, Ling, Ding, Hongyan, Du, Jikun
Format: Article
Language:English
Subjects:
Coenzyme Q10
Inflammatory
Neurology
NF–κB
β–amyloid25–35
Online Access:Get full text
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Description
Summary:Highlights • CoQ10 showed neuroprotective effects in Aβ25–35 –induced PC12 cells. • CoQ10 attenuated neuroinflammatory responses. • CoQ10 inactivated NF–κB dependent inflammatory pathways.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2017.04.014