The activation of 5-HT3 receptors evokes GABA release in the spinal cord

We carried out experiments using a microdialysis method to determine whether activation of 5-HT3 receptors increases the concentration of GABA in the dorsal horn of the spinal cord. Intrathecal perfusion of a selective 5-HT3 receptor agonist, 1-phenylbiguanide (0.3, 1.0, and 3.0 mM) dose-dependently...

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Bibliographic Details
Published in:Brain research 2003-07, Vol.978 (1-2), p.250-255
Main Authors: KAWAMATA, Tomoyuki, OMOTE, Keiichi, TORIYABE, Masaki, YAMAMOTO, Hiroki, NAMIKI, Akiyoshi
Format: Article
Language:English
Subjects:
Biological and medical sciences
Central nervous system
Central neurotransmission. Neuromudulation. Pathways and receptors
Fundamental and applied biological sciences. Psychology
Vertebrates: nervous system and sense organs
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Summary:We carried out experiments using a microdialysis method to determine whether activation of 5-HT3 receptors increases the concentration of GABA in the dorsal horn of the spinal cord. Intrathecal perfusion of a selective 5-HT3 receptor agonist, 1-phenylbiguanide (0.3, 1.0, and 3.0 mM) dose-dependently, increased GABA concentration, while concentrations of glutamate and glycine were not changed. The concentration of aspartate was increased only by 3.0 mM of 1-phenylbiguanide. Our results have provided direct evidence that activation of 5-HT3 receptors evokes GABA release in the spinal dorsal horn, possibly producing analgesia.
ISSN:0006-8993
1872-6240
DOI:10.1016/s0006-8993(03)02952-4