Supplementation with different teas from Camellia sinensis prevents memory deficits and hippocampus oxidative stress in ischemia-reperfusion

• Published in: Neurochemistry international 2017-09, Vol.108, p.287-295
• Main Authors: Martins, Alexandre, Schimidt, Helen L., Garcia, Alexandre, Colletta Altermann, Caroline Dalla, Santos, Francielli W., Carpes, Felipe P., da Silva, Weber Cláudio, Mello-Carpes, Pâmela B.
• Format: Article
• Language: English
• Subjects: Animals; Brain Ischemia - diet therapy; Brain Ischemia - metabolism; Camellia sinensis; Cognition; Green tea; Hippocampus - diagnostic imaging; Hippocampus - metabolism; Male; Maze Learning - drug effects; Maze Learning - physiology; Memory Disorders - metabolism; Memory Disorders - prevention & control; Neuroprotective Agents - isolation & purification; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; Oxidative status; Oxidative Stress - drug effects; Oxidative Stress - physiology; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Rats; Rats, Wistar; Recognition memory; Red tea; Reperfusion Injury - diet therapy; Reperfusion Injury - metabolism; Spatial memory; Tea
• ISSN: 0197-0186; 1872-9754
• DOI: 10.1016/j.neuint.2017.04.019

Memory and cognition impairments resultant of ischemic stroke could be minimized or avoided by antioxidant supplementation. In this regard, the neuroprotective potential of Green tea from Camellia sinensis has been investigated. However, there is a lack of information regarding the neuroprotective potential of others teas processed from the Camellia sinensis. Here we investigate the neuroprotective role of green, red, white and black tea on memory deficits and brain oxidative stress in a model of ischemic stroke in rats. Our findings show that green and red teas prevent deficits in object and social recognition memories, but only green tea protects against deficits in spatial memory and avoids hippocampal oxidative status and intense necrosis and others alterations in the brain tissue. In summary, green tea shows better neuroprotection in ischemic stroke than the others teas from Camellia sinensis. •White, green and red teas protect recognition memory deficit after ischemic stroke.•Only green tea protects against ischemic stroke induced spatial memory deficit.•Only green tea protects against hippocampal oxidative stress after ischemic stroke.•Neuroprotection is higher after green tea supplementation.