Prognostic and Clinicopathological Significance of ARID1A in Endometrium‐Related Gynecological Cancers: A Meta‐Analysis

• Published in: Journal of cellular biochemistry 2017-12, Vol.118 (12), p.4517-4525
• Main Authors: Liu, Guangquan, Xu, Pengfei, Fu, Ziyi, Hua, Xiangdong, Liu, Xiaoguang, Li, Wenqu, Zhang, Mi, Wu, Jiacong, Wen, Juan, Xu, Juan, Jia, Xuemei
• Format: Article
• Language: English
• Subjects: Adenocarcinoma, Clear Cell - metabolism; Adenocarcinoma, Clear Cell - mortality; Adenocarcinoma, Clear Cell - pathology; ARID1A; Carcinoma, Endometrioid - metabolism; Carcinoma, Endometrioid - mortality; Carcinoma, Endometrioid - pathology; CLINICAL FACTORS; Confidence intervals; Disease-Free Survival; Endometrial cancer; Endometrial Neoplasms - metabolism; Endometrial Neoplasms - mortality; Endometrial Neoplasms - pathology; Endometrium; ENDOMETRIUM‐RELATED GYNECOLOGICAL CANCERS; ENDOMTETRIOSIS; Female; Gynecological cancer; Gynecology; Humans; Meta-analysis; Neoplasm Proteins - metabolism; Nuclear Proteins - metabolism; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - mortality; Ovarian Neoplasms - pathology; Patients; PROGNOSIS; Survival Rate; Transcription Factors - metabolism; Tumor suppressor genes; Uterus
• ISSN: 0730-2312; 1097-4644
• DOI: 10.1002/jcb.26109

ABSTRACT The tumor suppressor gene, AT Rich Interactive Domain 1A (ARID1A) mutation has been reported in a variety of cancers, especially the endometrium‐related gynecological cancers, including the ovarian clear cell carcinoma, ovarian endometrioid carcinoma, and uterine endometrioid carcinoma. However, the prognostic value of ARID1A in endometrium‐related gynecological cancers is still inconclusive. Therefore, we performed this meta‐analysis to evaluate the clinical significance of ARID1A in endometrium‐related gynecological cancers. By systematically searching all the relevant studies from Pubmed, Cochrane Library, and Web of Science up to September 2016, 11 studies with 1,432 patients were included. All the study characteristics and the prognostic data were extracted. Hazard ratios (HRs) and 95% confidence intervals (CIs) were pooled using the fixed‐effect or random‐effect model. Our results indicated that negative ARID1A expression predicted shorter Progression free survival (PFS, HR, 1.84; 95%CI, 1.32–2.57, P = 0.000) of patients with endometrium related gynecological cancers, especially the patiently with OCCC and the patients in Japan. Besides, a marginal trend towards the same direction was found in the Overall analysis (OS, HR, 1.34; 95%CI, 0.93–1.93, P = 0.112). Furthermore, the significant correlation was achieved between the negative ARID1A expression and the FIGO stage of endometrium‐related gynecological cancers, but not the other characteristics. J. Cell. Biochem. 118: 4517–4525, 2017. © 2017 Wiley Periodicals, Inc. Our results indicated significant association between negative ARID1A expression and shorter PFS of patients with endometrium related gynecological cancers (HR, 1.84; 95%CI, 1.32–2.57, P = 0.000), especially the patients with Ovarian Clear Cell Carcinoma and the patients in Japan, but not Overall Survival.