Chronic NaHS treatment decreases oxidative stress and improves endothelial function in diabetic mice

Hydrogen sulphide (H2S) is endogenously produced in vascular tissue and has anti-oxidant and vasoprotective properties. This study investigates whether chronic treatment using the fast H2S donor NaHS could elicit a vasoprotective effect in diabetes. Diabetes was induced in male C57BL6/J mice with st...

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Published in:Diabetes & vascular disease research 2017-05, Vol.14 (3), p.246-253
Main Authors: Ng, Hooi H, Yildiz, Gunes S, Ku, Jacqueline M, Miller, Alyson A, Woodman, Owen L, Hart, Joanne L
Format: Article
Language:English
Subjects:
Animals
Antioxidants - administration & dosage
Blood Glucose - metabolism
Diabetes Mellitus, Experimental - blood
Diabetes Mellitus, Experimental - complications
Diabetes Mellitus, Experimental - drug therapy
Diabetic Angiopathies - etiology
Diabetic Angiopathies - metabolism
Diabetic Angiopathies - physiopathology
Diabetic Angiopathies - prevention & control
Dose-Response Relationship, Drug
Drug Administration Schedule
Endothelium, Vascular - drug effects
Endothelium, Vascular - metabolism
Endothelium, Vascular - physiopathology
Glycated Hemoglobin A - metabolism
Male
Mice, Inbred C57BL
Muscle, Smooth, Vascular - drug effects
Muscle, Smooth, Vascular - metabolism
Muscle, Smooth, Vascular - physiopathology
NADPH Oxidase 2 - metabolism
Nitric Oxide - metabolism
Nitric Oxide Donors - pharmacology
Nitric Oxide Synthase Type III - metabolism
Oxidative Stress - drug effects
Sulfides - administration & dosage
Superoxides - metabolism
Time Factors
Vasodilation - drug effects
Vasodilator Agents - pharmacology
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Summary:Hydrogen sulphide (H2S) is endogenously produced in vascular tissue and has anti-oxidant and vasoprotective properties. This study investigates whether chronic treatment using the fast H2S donor NaHS could elicit a vasoprotective effect in diabetes. Diabetes was induced in male C57BL6/J mice with streptozotocin (60 mg/kg daily, ip for 2 weeks) and confirmed by elevated blood glucose and glycated haemoglobin levels. Diabetic mice were then treated with NaHS (100 µmol/kg/day) for 4 weeks, and aortae collected for functional and biochemical analyses. In the diabetic group, both endothelium-dependent vasorelaxation and basal nitric oxide (NO•) bioactivity were significantly reduced (p 
ISSN:1479-1641
1752-8984
DOI:10.1177/1479164117692766