Ceylonins G–I: spongian diterpenes from the marine sponge Spongia ceylonensis

Three new spongian diterpenes, ceylonins G–I ( 1 – 3 ), were isolated from the marine sponge Spongia ceylonensis collected in Indonesia, together with five known spongian diterpenes ( 4 – 8 ). Only 4 inhibited USP7 with an IC 50 value of 8.2 μM.

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Bibliographic Details
Published in:Journal of natural medicines 2017-10, Vol.71 (4), p.765-769
Main Authors: El-Desoky, Ahmed H., Kato, Hikaru, Tsukamoto, Sachiko
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Complementary & Alternative Medicine
Diterpenes
Hydrocarbons
Marine biology
Medicinal Chemistry
Pharmacology/Toxicology
Pharmacy
Phytochemicals
Plant Sciences
Spongia
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Description
Summary:Three new spongian diterpenes, ceylonins G–I ( 1 – 3 ), were isolated from the marine sponge Spongia ceylonensis collected in Indonesia, together with five known spongian diterpenes ( 4 – 8 ). Only 4 inhibited USP7 with an IC 50 value of 8.2 μM.
ISSN:1340-3443
1861-0293
DOI:10.1007/s11418-017-1087-4