alpha sub(1) and alpha sub(2) domains of Aotus MHC Class I and Catarrhini MHC Class Ia share similar characteristics

Functional and structural analyses of major histocompatibility complex (MHC) class I molecules of the Aotus genus are necessary to validate it as a solid animal model for biomedical research. We thus isolated, cloned and sequenced exons 2 and 3 from three Aotus species (A. nancymaae, A. nigriceps an...

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Bibliographic Details
Published in:Tissue antigens 2003-05, Vol.61 (5), p.362-373
Main Authors: Suarez, C F, Cardenas, P P, Llanos-Ballestas, E J, Martinez, P, Obregon, M, Patarroyo, ME, Patarroyo, MA
Format: Article
Language:English
Subjects:
Aotus nancymaae
Aotus nigriceps
Aotus vociferans
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Summary:Functional and structural analyses of major histocompatibility complex (MHC) class I molecules of the Aotus genus are necessary to validate it as a solid animal model for biomedical research. We thus isolated, cloned and sequenced exons 2 and 3 from three Aotus species (A. nancymaae, A. nigriceps and A. vociferans). We found 24 sequences, which divided into two different groups (Ao-g1 and Ao-g2). A further sequence was identified as a processed pseudogene (Aona-PS2). Both sequence evolution and variability analyses showed that Ao-g1 and Ao-g2 display similar characteristics to Catarrhini's classical loci, such as positive selection pressure at the peptide binding region (PBR) high variability and a trans-specific evolution pattern.
ISSN:0001-2815
DOI:10.1034/j.1399-0039.2003.00045.x