Putative mechanisms of genotoxicity induced by fluoride: a comprehensive review

Genotoxicity is the ability of an agent to produce damage on the DNA molecule. Considering the strong evidence for a relationship between genetic damage and carcinogenesis, to elucidate the putative mechanisms of genotoxicity induced by fluoride are important to measure the degree of risk involved t...

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Bibliographic Details
Published in:Environmental science and pollution research international 2017-06, Vol.24 (18), p.15254-15259
Main Authors: Ribeiro, Daniel Araki, Yujra, Veronica Quispe, da Silva, Victor Hugo Pereira, Claudio, Samuel Rangel, Estadella, Debora, de Barros Viana, Milena, Oshima, Celina Tizuko Fujiyama
Format: Article
Language:English
Subjects:
Aquatic Pollution
Atmospheric Protection/Air Quality Control/Air Pollution
Carcinogenesis
Carcinogens
Cell cycle
Chromosome aberrations
Deoxyribonucleic acid
DNA
DNA Damage
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Health
Environmental science
Fluorides
Fluorides - toxicity
Genotoxicity
Human populations
Humans
Mitochondria
Mutagens - toxicity
Oxidative Stress
Review Article
Waste Water Technology
Water Management
Water Pollution Control
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Summary:Genotoxicity is the ability of an agent to produce damage on the DNA molecule. Considering the strong evidence for a relationship between genetic damage and carcinogenesis, to elucidate the putative mechanisms of genotoxicity induced by fluoride are important to measure the degree of risk involved to human populations. The purpose of this article is to provide a comprehensive review on genotoxicity induced by fluoride on the basis of its mechanisms of action. In the last 10 years, all published data showed some evidence related to genotoxicity, which is due to mitochondrial disruption, oxidative stress, and cell cycle disturbances. However, this is an area that still requires a lot of investigation since the published data are not sufficient for clarifying the genotoxicity induced by fluoride. Certainly, the new information will be added to those already established for regulatory purposes as a safe way to promote oral healthcare and prevent oral carcinogenesis.
ISSN:0944-1344
1614-7499
DOI:10.1007/s11356-017-9105-3