Stromal p16 Overexpression in Adult Granulosa Cell Tumors of the Ovary

Adult granulosa cell tumor of the ovary is usually diagnosed at an early stage. However, most patients with advanced or recurrent disease will die of the disease due to limited treatment options. Data on the stromal p16 expression of ovarian adult granulosa cell tumors are limited. The aim of this s...

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Bibliographic Details
Published in:Anticancer research 2017-05, Vol.37 (5), p.2437-2444
Main Authors: Na, Kiyong, Sung, Ji-Youn, Kim, Hyun-Soo
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers, Tumor - metabolism
Cyclin-Dependent Kinase Inhibitor p16 - metabolism
Female
Granulosa Cell Tumor - metabolism
Granulosa Cell Tumor - pathology
Humans
Middle Aged
Neoplasm Recurrence, Local - metabolism
Ovarian Neoplasms - metabolism
Ovarian Neoplasms - pathology
Ovary - metabolism
Sex Cord-Gonadal Stromal Tumors - metabolism
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Summary:Adult granulosa cell tumor of the ovary is usually diagnosed at an early stage. However, most patients with advanced or recurrent disease will die of the disease due to limited treatment options. Data on the stromal p16 expression of ovarian adult granulosa cell tumors are limited. The aim of this study was to analyze the immunohistochemical p16 expression in the peritumoral stroma of primary and recurrent adult granulosa cell tumors and investigate whether there were significant differences in stromal p16 expression among nonpathological ovaries, benign sex cord-stromal tumors, and adult granulosa cell tumors. This study included 13 and 11 cases of primary and recurrent adult granulosa cell tumors, respectively. Non-pathological ovaries and benign sex cord-stromal tumors showed negative or weak positive expression, whereas most of the adult granulosa cell tumors showed diffuse and moderate-to-strong immunostaining. Primary adult granulosa cell tumors had significantly higher stromal p16 expression levels than nonpathological ovaries and benign sex cord-stromal tumors (p
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.11583