PKB/Akt-dependent regulation of inflammation in cancer

Abstract Chronic inflammation is a major cause of human cancer. Clinical cancer therapies against inflammatory risk factors are strategically determined. To rationally guide a novel drug development, an improved mechanistic understanding on the pathological connection between inflammation and carcin...

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Bibliographic Details
Published in:Seminars in cancer biology 2018-02, Vol.48, p.62-69
Main Authors: Tang, Fengyuan, Wang, Yuhua, Hemmings, Brian A, Rüegg, Curzio, Xue, Gongda
Format: Article
Language:English
Subjects:
Chronic inflammation
Hematology, Oncology and Palliative Medicine
Immune surveillance
Immunogenic cancer progression
Intratumoral immune response
Oncogenic signaling
Protein kinase B
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Summary:Abstract Chronic inflammation is a major cause of human cancer. Clinical cancer therapies against inflammatory risk factors are strategically determined. To rationally guide a novel drug development, an improved mechanistic understanding on the pathological connection between inflammation and carcinogenesis is essential. PI3K-PKB signaling axis has been extensively studied and shown to be one of the key oncogenic drivers in most types of cancer. Pharmacological inhibition of the components along this signaling axis is of great interest for developing novel therapies. Interestingly, emerging studies have shown a close association between PKB activation and inflammatory activity in the vicinity of the tumor, and either blockade of PKB or attenuation of para-tumoral inflammation reveals a mutual-interactive pattern through pathway crosstalk. In this review, we intend to discuss recent advances of PKB-regulated chronic inflammation and its potential impacts on tumor development.
ISSN:1044-579X
1096-3650
DOI:10.1016/j.semcancer.2017.04.018