Alterations in post-movement beta event related synchronization throughout the migraine cycle: A controlled, longitudinal study

Background The migraine brain is believed to have altered cortical excitability compared to controls and between migraine cycle phases. Our aim was to evaluate post-activation excitability through post-movement beta event related synchronization (PMBS) in sensorimotor cortices with and without senso...

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Bibliographic Details
Published in:Cephalalgia 2018-04, Vol.38 (4), p.718-729
Main Authors: Mykland, Martin Syvertsen, Bjørk, Marte Helene, Stjern, Marit, Sand, Trond
Format: Article
Language:English
Subjects:
Adult
Aged
Beta Rhythm - physiology
Electroencephalography Phase Synchronization - physiology
Female
Humans
Longitudinal Studies
Male
Middle Aged
Migraine Disorders - physiopathology
Movement - physiology
Sensorimotor Cortex - physiopathology
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Summary:Background The migraine brain is believed to have altered cortical excitability compared to controls and between migraine cycle phases. Our aim was to evaluate post-activation excitability through post-movement beta event related synchronization (PMBS) in sensorimotor cortices with and without sensory discrimination. Subjects and methods We recorded EEG of 41 migraine patients and 31 healthy controls on three different days with classification of days in relation to migraine phases. During each recording, subjects performed one motor and one sensorimotor task with the right wrist. Controls and migraine patients in the interictal phase were compared with repeated measures (R-) ANOVA and two sample Student’s t-test. Migraine phases were compared to the interictal phase with R-ANOVA and paired Student’s t-test. Results The difference between PMBS at the contralateral and ipsilateral sensorimotor cortex was altered throughout the migraine cycle. Compared to the interictal phase, we found decreased PMBS at the ipsilateral sensorimotor cortex in the ictal phase and increased PMBS in the preictal phase. Lower ictal PMBS was found in bilateral sensorimotor cortices in patients with right side headache predominance. Conclusion The cyclic changes of PMBS in migraine patients may indicate that a dysfunction in deactivation and interhemispheric inhibition of the sensorimotor cortex is involved in the migraine attack cascade.
ISSN:0333-1024
1468-2982
DOI:10.1177/0333102417709011