Aldosterone concentrations in saliva reflect the duration and severity of depressive episode in a sex dependent manner

Abstract Evidence is accumulating that aldosterone may exert central actions and influence mental functions. The aim of the present study was to test the hypothesis that major depressive disorder affects the diurnal variation of salivary aldosterone and that aldosterone concentrations reflect the du...

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Bibliographic Details
Published in:Journal of psychiatric research 2017-08, Vol.91, p.164-168
Main Authors: Segeda, V, Izakova, L, Hlavacova, N, Bednarova, A, Jezova, D
Format: Article
Language:English
Subjects:
Adult
Aged
Aldosterone
Aldosterone - metabolism
Analysis of Variance
Circadian Rhythm
Depression
Depressive Disorder, Major - metabolism
Depressive Disorder, Major - physiopathology
Female
Humans
Male
Middle Aged
Psychiatric Status Rating Scales
Psychiatry
Radioimmunoassay
Saliva
Saliva - metabolism
Sex
Sex Characteristics
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Summary:Abstract Evidence is accumulating that aldosterone may exert central actions and influence mental functions. The aim of the present study was to test the hypothesis that major depressive disorder affects the diurnal variation of salivary aldosterone and that aldosterone concentrations reflect the duration and severity of the depressive episode in a sex dependent manner. The sample consisted of 60 patients (37 postmenopausal women, 23 men) with major depressive disorder. Patients were examined two times, in acute depressive episode (admission to the hospital) and after reaching clinical remission (discharge). The samples of saliva were taken by the patients themselves twice a day (8.00–9.00 h in the morning and in the evening). Aldosterone concentrations were significantly higher in women compared to men and were significantly higher at the time of admission to the hospital compared to those at the discharge. Morning but not evening salivary aldosterone concentrations reflected the length of the depressive episode in women as well as the severity of the disorder in both sexes. Moreover, the patients with depression failed to exert known daily rhythmicity of aldosterone release. The present study brings several pieces of evidence suggesting the association of aldosterone with the pathophysiology of depression. Salivary aldosterone concentrations appear to reflect the outcome, the duration and the severity of the depressive episode in a sex dependent manner.
ISSN:0022-3956
1879-1379
DOI:10.1016/j.jpsychires.2017.04.011