Shifting from constant-voltage to constant-current in Parkinson’s disease patients with chronic stimulation

The study aimed to evaluate safety and efficacy of shifting stimulation settings from constant-voltage (CV) to constant-current (CC) programming in patients with Parkinson’s disease (PD) and chronic subthalamic nucleus deep brain stimulation (STN DBS). Twenty PD patients with chronic STN DBS set in...

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Bibliographic Details
Published in:Neurological sciences 2017-08, Vol.38 (8), p.1505-1508
Main Authors: Amami, P., Mascia, M. M., Franzini, A., Saba, F., Albanese, A.
Format: Article
Language:English
Subjects:
Brief Communication
Deep brain stimulation
Deep Brain Stimulation - methods
Electrical stimuli
Executive function
Female
Follow-Up Studies
Humans
Inhibition (Psychology)
Male
Medicine
Medicine & Public Health
Motor task performance
Movement disorders
Neurodegenerative diseases
Neurology
Neuropsychological Tests
Neuroradiology
Neurosciences
Neurosurgery
Parkinson Disease - therapy
Parkinson's disease
Prospective Studies
Psychiatry
Side effects
Solitary tract nucleus
Statistics, Nonparametric
Subthalamic nucleus
Subthalamic Nucleus - physiology
Voltage
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Summary:The study aimed to evaluate safety and efficacy of shifting stimulation settings from constant-voltage (CV) to constant-current (CC) programming in patients with Parkinson’s disease (PD) and chronic subthalamic nucleus deep brain stimulation (STN DBS). Twenty PD patients with chronic STN DBS set in CV programming were shifted to CC and followed for 3 months; the other stimulation settings and the medication regimen remained unchanged. Side effects, motor, non-motor, executive functions, and impedance were assessed at baseline and during follow-up. No adverse events were observed at time of shifting or during CC stimulation. Motor and non-motor measures remained unchanged at follow-up despite impedance decreased. Compared to baseline, inhibition processes improved at follow-up. The shifting strategy was well tolerated and the clinical outcome was maintained with no need to adjust stimulation settings or medications notwithstanding a decrease of impedance. Improvement of inhibition processes is a finding which needed further investigation.
ISSN:1590-1874
1590-3478
DOI:10.1007/s10072-017-2961-2