Amelioration of CCl4-induced liver injury in rats by selenizing Astragalus polysaccharides: Role of proinflammatory cytokines, oxidative stress and hepatic stellate cells

Selenizing Astragalus polysaccharides (sAPS) were prepared by nitric acid–sodium selenite method. Effect of sAPS on carbon tetrachloride (CCl4)-induced liver injury and the underlying mechanisms were investigated in the rat. Forty male Wistar rats were divided into five equal groups as follows: cont...

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Bibliographic Details
Published in:Research in veterinary science 2017-10, Vol.114, p.202-211
Main Authors: Hamid, Mohammed, Liu, Dandan, Abdulrahim, Yassin, Liu, Yunhuan, Qian, Gang, Khan, Alamzeb, Gan, Fang, Huang, Kehe
Format: Article
Language:English
Subjects:
CCl4
Liver injury
Oxidative stress
Proinflammatory cytokines
Rats
Selenizing Astragalus polysaccharides
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Summary:Selenizing Astragalus polysaccharides (sAPS) were prepared by nitric acid–sodium selenite method. Effect of sAPS on carbon tetrachloride (CCl4)-induced liver injury and the underlying mechanisms were investigated in the rat. Forty male Wistar rats were divided into five equal groups as follows: control group; CCl4 group; CCl4+Astragalus polysaccharides group; CCl4+sodium selenite group and CCl4+selenizing Astragalus polysaccharides group. The results showed that sAPS significantly decreased the levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase in the serum, malondialdehyde and hydroxyproline content in liver (P
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2017.05.002