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The association of thiol/disulphide homeostasis and lipid accumulation index with cardiovascular risk factors in overweight adolescents with polycystic ovary syndrome

Summary Objective To assess thiol/disulphide homeostasis and lipid accumulation product index, and to determine whether they are associated with increased cardiovascular disease (CVD) risk or not in overweight adolescents with polycystic ovary syndrome (PCOS). Design Case–control study. Setting Educ...

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Published in:Clinical endocrinology (Oxford) 2016-04, Vol.84 (4), p.516-523
Main Authors: Ozler, Sibel, Oztas, Efser, Tokmak, Aytekin, Ergin, Merve, Isci, Esra, Eren, Funda, Pehlivan, Selcen, Neselioglu, Salim, Yılmaz, Nafiye
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container_title Clinical endocrinology (Oxford)
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creator Ozler, Sibel
Oztas, Efser
Tokmak, Aytekin
Ergin, Merve
Isci, Esra
Eren, Funda
Pehlivan, Selcen
Neselioglu, Salim
Yılmaz, Nafiye
description Summary Objective To assess thiol/disulphide homeostasis and lipid accumulation product index, and to determine whether they are associated with increased cardiovascular disease (CVD) risk or not in overweight adolescents with polycystic ovary syndrome (PCOS). Design Case–control study. Setting Education and Research Hospital. Patients Group 1: 43 overweight+PCOS, Group 2: 45 normal weight+PCOS, Group 3: 27 overweight adolescents and Group 4: 96 age‐matched, normal weight healthy controls. Interventions Serum lipid profiles, hormonal parameters and thiol/disulphide homeostasis were measured. Lipid accumulation index (LAP index) and homeostasis model assessment (HOMA‐IR) were calculated. Main outcome measures The relation between thiol/disulphide homeostasis and LAP index, and increased CVD risk were evaluated in overweight adolescents with PCOS. Results Native and total thiol levels were significantly lower in overweight+PCOS adolescents when compared with both normal weight PCOS and control adolescents (P = 0·002). LAP index values were significantly higher in Group 1 when compared separately with the rest of the three groups (P < 0·001). Multivariable logistic regression analysis revealed serum total thiol levels of lower than 405·45 μmol/l were independently associated with increased risk of CVD in overweight PCOS adolescents (OR: 1·019, 95% CI: 1·001–1·036). In addition, a LAP index greater than 21·54 was also associated with increased CVD risk in overweight PCOS adolescents (OR: 1·270, 95% CI: 1·174–1·374). Conclusion In conclusion, we suggest that increased LAP index and decreased total thiol levels may contribute to the increased CVD risk in overweight adolescents with PCOS.
doi_str_mv 10.1111/cen.12965
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Design Case–control study. Setting Education and Research Hospital. Patients Group 1: 43 overweight+PCOS, Group 2: 45 normal weight+PCOS, Group 3: 27 overweight adolescents and Group 4: 96 age‐matched, normal weight healthy controls. Interventions Serum lipid profiles, hormonal parameters and thiol/disulphide homeostasis were measured. Lipid accumulation index (LAP index) and homeostasis model assessment (HOMA‐IR) were calculated. Main outcome measures The relation between thiol/disulphide homeostasis and LAP index, and increased CVD risk were evaluated in overweight adolescents with PCOS. Results Native and total thiol levels were significantly lower in overweight+PCOS adolescents when compared with both normal weight PCOS and control adolescents (P = 0·002). LAP index values were significantly higher in Group 1 when compared separately with the rest of the three groups (P &lt; 0·001). Multivariable logistic regression analysis revealed serum total thiol levels of lower than 405·45 μmol/l were independently associated with increased risk of CVD in overweight PCOS adolescents (OR: 1·019, 95% CI: 1·001–1·036). In addition, a LAP index greater than 21·54 was also associated with increased CVD risk in overweight PCOS adolescents (OR: 1·270, 95% CI: 1·174–1·374). Conclusion In conclusion, we suggest that increased LAP index and decreased total thiol levels may contribute to the increased CVD risk in overweight adolescents with PCOS.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/cen.12965</identifier><identifier>PMID: 26492953</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - physiopathology ; Case-Control Studies ; Disulfides - blood ; Female ; Homeostasis ; Humans ; Lipids - blood ; Logistic Models ; Multivariate Analysis ; Obesity - blood ; Obesity - physiopathology ; Overweight - blood ; Overweight - physiopathology ; Polycystic Ovary Syndrome - blood ; Polycystic Ovary Syndrome - physiopathology ; Risk Assessment ; Risk Factors ; Sulfhydryl Compounds - blood</subject><ispartof>Clinical endocrinology (Oxford), 2016-04, Vol.84 (4), p.516-523</ispartof><rights>2015 John Wiley &amp; Sons Ltd</rights><rights>2015 John Wiley &amp; Sons Ltd.</rights><rights>Copyright © 2016 John Wiley &amp; Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4945-5fb5f86ab2bae7ab13203e123027d56f30bcad3e47b6c7e30657b3c73a2639c53</citedby><cites>FETCH-LOGICAL-c4945-5fb5f86ab2bae7ab13203e123027d56f30bcad3e47b6c7e30657b3c73a2639c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26492953$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ozler, Sibel</creatorcontrib><creatorcontrib>Oztas, Efser</creatorcontrib><creatorcontrib>Tokmak, Aytekin</creatorcontrib><creatorcontrib>Ergin, Merve</creatorcontrib><creatorcontrib>Isci, Esra</creatorcontrib><creatorcontrib>Eren, Funda</creatorcontrib><creatorcontrib>Pehlivan, Selcen</creatorcontrib><creatorcontrib>Neselioglu, Salim</creatorcontrib><creatorcontrib>Yılmaz, Nafiye</creatorcontrib><title>The association of thiol/disulphide homeostasis and lipid accumulation index with cardiovascular risk factors in overweight adolescents with polycystic ovary syndrome</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol</addtitle><description>Summary Objective To assess thiol/disulphide homeostasis and lipid accumulation product index, and to determine whether they are associated with increased cardiovascular disease (CVD) risk or not in overweight adolescents with polycystic ovary syndrome (PCOS). Design Case–control study. Setting Education and Research Hospital. Patients Group 1: 43 overweight+PCOS, Group 2: 45 normal weight+PCOS, Group 3: 27 overweight adolescents and Group 4: 96 age‐matched, normal weight healthy controls. Interventions Serum lipid profiles, hormonal parameters and thiol/disulphide homeostasis were measured. Lipid accumulation index (LAP index) and homeostasis model assessment (HOMA‐IR) were calculated. Main outcome measures The relation between thiol/disulphide homeostasis and LAP index, and increased CVD risk were evaluated in overweight adolescents with PCOS. Results Native and total thiol levels were significantly lower in overweight+PCOS adolescents when compared with both normal weight PCOS and control adolescents (P = 0·002). LAP index values were significantly higher in Group 1 when compared separately with the rest of the three groups (P &lt; 0·001). Multivariable logistic regression analysis revealed serum total thiol levels of lower than 405·45 μmol/l were independently associated with increased risk of CVD in overweight PCOS adolescents (OR: 1·019, 95% CI: 1·001–1·036). In addition, a LAP index greater than 21·54 was also associated with increased CVD risk in overweight PCOS adolescents (OR: 1·270, 95% CI: 1·174–1·374). 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Calcified Tissue Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Physical Education Index</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozler, Sibel</au><au>Oztas, Efser</au><au>Tokmak, Aytekin</au><au>Ergin, Merve</au><au>Isci, Esra</au><au>Eren, Funda</au><au>Pehlivan, Selcen</au><au>Neselioglu, Salim</au><au>Yılmaz, Nafiye</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association of thiol/disulphide homeostasis and lipid accumulation index with cardiovascular risk factors in overweight adolescents with polycystic ovary syndrome</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol</addtitle><date>2016-04</date><risdate>2016</risdate><volume>84</volume><issue>4</issue><spage>516</spage><epage>523</epage><pages>516-523</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><abstract>Summary Objective To assess thiol/disulphide homeostasis and lipid accumulation product index, and to determine whether they are associated with increased cardiovascular disease (CVD) risk or not in overweight adolescents with polycystic ovary syndrome (PCOS). Design Case–control study. Setting Education and Research Hospital. Patients Group 1: 43 overweight+PCOS, Group 2: 45 normal weight+PCOS, Group 3: 27 overweight adolescents and Group 4: 96 age‐matched, normal weight healthy controls. Interventions Serum lipid profiles, hormonal parameters and thiol/disulphide homeostasis were measured. Lipid accumulation index (LAP index) and homeostasis model assessment (HOMA‐IR) were calculated. Main outcome measures The relation between thiol/disulphide homeostasis and LAP index, and increased CVD risk were evaluated in overweight adolescents with PCOS. Results Native and total thiol levels were significantly lower in overweight+PCOS adolescents when compared with both normal weight PCOS and control adolescents (P = 0·002). LAP index values were significantly higher in Group 1 when compared separately with the rest of the three groups (P &lt; 0·001). Multivariable logistic regression analysis revealed serum total thiol levels of lower than 405·45 μmol/l were independently associated with increased risk of CVD in overweight PCOS adolescents (OR: 1·019, 95% CI: 1·001–1·036). In addition, a LAP index greater than 21·54 was also associated with increased CVD risk in overweight PCOS adolescents (OR: 1·270, 95% CI: 1·174–1·374). Conclusion In conclusion, we suggest that increased LAP index and decreased total thiol levels may contribute to the increased CVD risk in overweight adolescents with PCOS.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>26492953</pmid><doi>10.1111/cen.12965</doi><tpages>8</tpages></addata></record>
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ispartof Clinical endocrinology (Oxford), 2016-04, Vol.84 (4), p.516-523
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language eng
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source Wiley-Blackwell Read & Publish Collection
subjects Adolescent
Cardiovascular Diseases - blood
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - physiopathology
Case-Control Studies
Disulfides - blood
Female
Homeostasis
Humans
Lipids - blood
Logistic Models
Multivariate Analysis
Obesity - blood
Obesity - physiopathology
Overweight - blood
Overweight - physiopathology
Polycystic Ovary Syndrome - blood
Polycystic Ovary Syndrome - physiopathology
Risk Assessment
Risk Factors
Sulfhydryl Compounds - blood
title The association of thiol/disulphide homeostasis and lipid accumulation index with cardiovascular risk factors in overweight adolescents with polycystic ovary syndrome
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