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The association of thiol/disulphide homeostasis and lipid accumulation index with cardiovascular risk factors in overweight adolescents with polycystic ovary syndrome
Summary Objective To assess thiol/disulphide homeostasis and lipid accumulation product index, and to determine whether they are associated with increased cardiovascular disease (CVD) risk or not in overweight adolescents with polycystic ovary syndrome (PCOS). Design Case–control study. Setting Educ...
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Published in: | Clinical endocrinology (Oxford) 2016-04, Vol.84 (4), p.516-523 |
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container_title | Clinical endocrinology (Oxford) |
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creator | Ozler, Sibel Oztas, Efser Tokmak, Aytekin Ergin, Merve Isci, Esra Eren, Funda Pehlivan, Selcen Neselioglu, Salim Yılmaz, Nafiye |
description | Summary
Objective
To assess thiol/disulphide homeostasis and lipid accumulation product index, and to determine whether they are associated with increased cardiovascular disease (CVD) risk or not in overweight adolescents with polycystic ovary syndrome (PCOS).
Design
Case–control study.
Setting
Education and Research Hospital.
Patients
Group 1: 43 overweight+PCOS, Group 2: 45 normal weight+PCOS, Group 3: 27 overweight adolescents and Group 4: 96 age‐matched, normal weight healthy controls.
Interventions
Serum lipid profiles, hormonal parameters and thiol/disulphide homeostasis were measured. Lipid accumulation index (LAP index) and homeostasis model assessment (HOMA‐IR) were calculated.
Main outcome measures
The relation between thiol/disulphide homeostasis and LAP index, and increased CVD risk were evaluated in overweight adolescents with PCOS.
Results
Native and total thiol levels were significantly lower in overweight+PCOS adolescents when compared with both normal weight PCOS and control adolescents (P = 0·002). LAP index values were significantly higher in Group 1 when compared separately with the rest of the three groups (P < 0·001). Multivariable logistic regression analysis revealed serum total thiol levels of lower than 405·45 μmol/l were independently associated with increased risk of CVD in overweight PCOS adolescents (OR: 1·019, 95% CI: 1·001–1·036). In addition, a LAP index greater than 21·54 was also associated with increased CVD risk in overweight PCOS adolescents (OR: 1·270, 95% CI: 1·174–1·374).
Conclusion
In conclusion, we suggest that increased LAP index and decreased total thiol levels may contribute to the increased CVD risk in overweight adolescents with PCOS. |
doi_str_mv | 10.1111/cen.12965 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1897369506</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1773232462</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4945-5fb5f86ab2bae7ab13203e123027d56f30bcad3e47b6c7e30657b3c73a2639c53</originalsourceid><addsrcrecordid>eNqFkc1u1DAUhS0EosPAghdAltjAIh3Hju3JEg2lIKoiRBESG8uxHeI2iYNv0mleiOfEQ9oukBDe3IW_c-7PQeh5To7z9DbG9cc5LQV_gFY5EzyjVPCHaEUYIRkRojhCTwAuCSF8S-RjdERFUdKSsxX6ddE4rAGC8Xr0ocehxmPjQ7uxHqZ2aLx1uAmdCzBq8IB1b3HrB2-xNmbqpnaR-d66G7z3Y4ONjtaHaw0mfUYcPVzhWpsxREgYDtcu7p3_0YxY29A6SNOPsEiH0M5mhtGbhOk4Y5h7G1P3p-hRrVtwz27rGn19d3Kxe5-dfTr9sHtzlpmiLHjG64rXW6ErWmkndZUzSpjLKSNUWi5qRiqjLXOFrISRjhHBZcWMZJoKVhrO1ujV4jvE8HNyMKrOpwHbVvcuTKDybSmZKDkR_0elZJTRQtCEvvwLvQxT7NMiB4oW5fYQxhq9XigTA0B0tRqi79IVVE7UIWeVLqX-5JzYF7eOU9U5e0_eBZuAzQLsfevmfzup3cn5nWW2KDyM7uZeoeOVEpJJrr6dn6q3-eePnH7J1Xf2G3RqxNI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1772498295</pqid></control><display><type>article</type><title>The association of thiol/disulphide homeostasis and lipid accumulation index with cardiovascular risk factors in overweight adolescents with polycystic ovary syndrome</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Ozler, Sibel ; Oztas, Efser ; Tokmak, Aytekin ; Ergin, Merve ; Isci, Esra ; Eren, Funda ; Pehlivan, Selcen ; Neselioglu, Salim ; Yılmaz, Nafiye</creator><creatorcontrib>Ozler, Sibel ; Oztas, Efser ; Tokmak, Aytekin ; Ergin, Merve ; Isci, Esra ; Eren, Funda ; Pehlivan, Selcen ; Neselioglu, Salim ; Yılmaz, Nafiye</creatorcontrib><description>Summary
Objective
To assess thiol/disulphide homeostasis and lipid accumulation product index, and to determine whether they are associated with increased cardiovascular disease (CVD) risk or not in overweight adolescents with polycystic ovary syndrome (PCOS).
Design
Case–control study.
Setting
Education and Research Hospital.
Patients
Group 1: 43 overweight+PCOS, Group 2: 45 normal weight+PCOS, Group 3: 27 overweight adolescents and Group 4: 96 age‐matched, normal weight healthy controls.
Interventions
Serum lipid profiles, hormonal parameters and thiol/disulphide homeostasis were measured. Lipid accumulation index (LAP index) and homeostasis model assessment (HOMA‐IR) were calculated.
Main outcome measures
The relation between thiol/disulphide homeostasis and LAP index, and increased CVD risk were evaluated in overweight adolescents with PCOS.
Results
Native and total thiol levels were significantly lower in overweight+PCOS adolescents when compared with both normal weight PCOS and control adolescents (P = 0·002). LAP index values were significantly higher in Group 1 when compared separately with the rest of the three groups (P < 0·001). Multivariable logistic regression analysis revealed serum total thiol levels of lower than 405·45 μmol/l were independently associated with increased risk of CVD in overweight PCOS adolescents (OR: 1·019, 95% CI: 1·001–1·036). In addition, a LAP index greater than 21·54 was also associated with increased CVD risk in overweight PCOS adolescents (OR: 1·270, 95% CI: 1·174–1·374).
Conclusion
In conclusion, we suggest that increased LAP index and decreased total thiol levels may contribute to the increased CVD risk in overweight adolescents with PCOS.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/cen.12965</identifier><identifier>PMID: 26492953</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - physiopathology ; Case-Control Studies ; Disulfides - blood ; Female ; Homeostasis ; Humans ; Lipids - blood ; Logistic Models ; Multivariate Analysis ; Obesity - blood ; Obesity - physiopathology ; Overweight - blood ; Overweight - physiopathology ; Polycystic Ovary Syndrome - blood ; Polycystic Ovary Syndrome - physiopathology ; Risk Assessment ; Risk Factors ; Sulfhydryl Compounds - blood</subject><ispartof>Clinical endocrinology (Oxford), 2016-04, Vol.84 (4), p.516-523</ispartof><rights>2015 John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons Ltd.</rights><rights>Copyright © 2016 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4945-5fb5f86ab2bae7ab13203e123027d56f30bcad3e47b6c7e30657b3c73a2639c53</citedby><cites>FETCH-LOGICAL-c4945-5fb5f86ab2bae7ab13203e123027d56f30bcad3e47b6c7e30657b3c73a2639c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26492953$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ozler, Sibel</creatorcontrib><creatorcontrib>Oztas, Efser</creatorcontrib><creatorcontrib>Tokmak, Aytekin</creatorcontrib><creatorcontrib>Ergin, Merve</creatorcontrib><creatorcontrib>Isci, Esra</creatorcontrib><creatorcontrib>Eren, Funda</creatorcontrib><creatorcontrib>Pehlivan, Selcen</creatorcontrib><creatorcontrib>Neselioglu, Salim</creatorcontrib><creatorcontrib>Yılmaz, Nafiye</creatorcontrib><title>The association of thiol/disulphide homeostasis and lipid accumulation index with cardiovascular risk factors in overweight adolescents with polycystic ovary syndrome</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol</addtitle><description>Summary
Objective
To assess thiol/disulphide homeostasis and lipid accumulation product index, and to determine whether they are associated with increased cardiovascular disease (CVD) risk or not in overweight adolescents with polycystic ovary syndrome (PCOS).
Design
Case–control study.
Setting
Education and Research Hospital.
Patients
Group 1: 43 overweight+PCOS, Group 2: 45 normal weight+PCOS, Group 3: 27 overweight adolescents and Group 4: 96 age‐matched, normal weight healthy controls.
Interventions
Serum lipid profiles, hormonal parameters and thiol/disulphide homeostasis were measured. Lipid accumulation index (LAP index) and homeostasis model assessment (HOMA‐IR) were calculated.
Main outcome measures
The relation between thiol/disulphide homeostasis and LAP index, and increased CVD risk were evaluated in overweight adolescents with PCOS.
Results
Native and total thiol levels were significantly lower in overweight+PCOS adolescents when compared with both normal weight PCOS and control adolescents (P = 0·002). LAP index values were significantly higher in Group 1 when compared separately with the rest of the three groups (P < 0·001). Multivariable logistic regression analysis revealed serum total thiol levels of lower than 405·45 μmol/l were independently associated with increased risk of CVD in overweight PCOS adolescents (OR: 1·019, 95% CI: 1·001–1·036). In addition, a LAP index greater than 21·54 was also associated with increased CVD risk in overweight PCOS adolescents (OR: 1·270, 95% CI: 1·174–1·374).
Conclusion
In conclusion, we suggest that increased LAP index and decreased total thiol levels may contribute to the increased CVD risk in overweight adolescents with PCOS.</description><subject>Adolescent</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>Case-Control Studies</subject><subject>Disulfides - blood</subject><subject>Female</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Lipids - blood</subject><subject>Logistic Models</subject><subject>Multivariate Analysis</subject><subject>Obesity - blood</subject><subject>Obesity - physiopathology</subject><subject>Overweight - blood</subject><subject>Overweight - physiopathology</subject><subject>Polycystic Ovary Syndrome - blood</subject><subject>Polycystic Ovary Syndrome - physiopathology</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Sulfhydryl Compounds - blood</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFkc1u1DAUhS0EosPAghdAltjAIh3Hju3JEg2lIKoiRBESG8uxHeI2iYNv0mleiOfEQ9oukBDe3IW_c-7PQeh5To7z9DbG9cc5LQV_gFY5EzyjVPCHaEUYIRkRojhCTwAuCSF8S-RjdERFUdKSsxX6ddE4rAGC8Xr0ocehxmPjQ7uxHqZ2aLx1uAmdCzBq8IB1b3HrB2-xNmbqpnaR-d66G7z3Y4ONjtaHaw0mfUYcPVzhWpsxREgYDtcu7p3_0YxY29A6SNOPsEiH0M5mhtGbhOk4Y5h7G1P3p-hRrVtwz27rGn19d3Kxe5-dfTr9sHtzlpmiLHjG64rXW6ErWmkndZUzSpjLKSNUWi5qRiqjLXOFrISRjhHBZcWMZJoKVhrO1ujV4jvE8HNyMKrOpwHbVvcuTKDybSmZKDkR_0elZJTRQtCEvvwLvQxT7NMiB4oW5fYQxhq9XigTA0B0tRqi79IVVE7UIWeVLqX-5JzYF7eOU9U5e0_eBZuAzQLsfevmfzup3cn5nWW2KDyM7uZeoeOVEpJJrr6dn6q3-eePnH7J1Xf2G3RqxNI</recordid><startdate>201604</startdate><enddate>201604</enddate><creator>Ozler, Sibel</creator><creator>Oztas, Efser</creator><creator>Tokmak, Aytekin</creator><creator>Ergin, Merve</creator><creator>Isci, Esra</creator><creator>Eren, Funda</creator><creator>Pehlivan, Selcen</creator><creator>Neselioglu, Salim</creator><creator>Yılmaz, Nafiye</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7TS</scope></search><sort><creationdate>201604</creationdate><title>The association of thiol/disulphide homeostasis and lipid accumulation index with cardiovascular risk factors in overweight adolescents with polycystic ovary syndrome</title><author>Ozler, Sibel ; Oztas, Efser ; Tokmak, Aytekin ; Ergin, Merve ; Isci, Esra ; Eren, Funda ; Pehlivan, Selcen ; Neselioglu, Salim ; Yılmaz, Nafiye</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4945-5fb5f86ab2bae7ab13203e123027d56f30bcad3e47b6c7e30657b3c73a2639c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - diagnosis</topic><topic>Cardiovascular Diseases - physiopathology</topic><topic>Case-Control Studies</topic><topic>Disulfides - blood</topic><topic>Female</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Lipids - blood</topic><topic>Logistic Models</topic><topic>Multivariate Analysis</topic><topic>Obesity - blood</topic><topic>Obesity - physiopathology</topic><topic>Overweight - blood</topic><topic>Overweight - physiopathology</topic><topic>Polycystic Ovary Syndrome - blood</topic><topic>Polycystic Ovary Syndrome - physiopathology</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Sulfhydryl Compounds - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ozler, Sibel</creatorcontrib><creatorcontrib>Oztas, Efser</creatorcontrib><creatorcontrib>Tokmak, Aytekin</creatorcontrib><creatorcontrib>Ergin, Merve</creatorcontrib><creatorcontrib>Isci, Esra</creatorcontrib><creatorcontrib>Eren, Funda</creatorcontrib><creatorcontrib>Pehlivan, Selcen</creatorcontrib><creatorcontrib>Neselioglu, Salim</creatorcontrib><creatorcontrib>Yılmaz, Nafiye</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Physical Education Index</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozler, Sibel</au><au>Oztas, Efser</au><au>Tokmak, Aytekin</au><au>Ergin, Merve</au><au>Isci, Esra</au><au>Eren, Funda</au><au>Pehlivan, Selcen</au><au>Neselioglu, Salim</au><au>Yılmaz, Nafiye</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association of thiol/disulphide homeostasis and lipid accumulation index with cardiovascular risk factors in overweight adolescents with polycystic ovary syndrome</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol</addtitle><date>2016-04</date><risdate>2016</risdate><volume>84</volume><issue>4</issue><spage>516</spage><epage>523</epage><pages>516-523</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><abstract>Summary
Objective
To assess thiol/disulphide homeostasis and lipid accumulation product index, and to determine whether they are associated with increased cardiovascular disease (CVD) risk or not in overweight adolescents with polycystic ovary syndrome (PCOS).
Design
Case–control study.
Setting
Education and Research Hospital.
Patients
Group 1: 43 overweight+PCOS, Group 2: 45 normal weight+PCOS, Group 3: 27 overweight adolescents and Group 4: 96 age‐matched, normal weight healthy controls.
Interventions
Serum lipid profiles, hormonal parameters and thiol/disulphide homeostasis were measured. Lipid accumulation index (LAP index) and homeostasis model assessment (HOMA‐IR) were calculated.
Main outcome measures
The relation between thiol/disulphide homeostasis and LAP index, and increased CVD risk were evaluated in overweight adolescents with PCOS.
Results
Native and total thiol levels were significantly lower in overweight+PCOS adolescents when compared with both normal weight PCOS and control adolescents (P = 0·002). LAP index values were significantly higher in Group 1 when compared separately with the rest of the three groups (P < 0·001). Multivariable logistic regression analysis revealed serum total thiol levels of lower than 405·45 μmol/l were independently associated with increased risk of CVD in overweight PCOS adolescents (OR: 1·019, 95% CI: 1·001–1·036). In addition, a LAP index greater than 21·54 was also associated with increased CVD risk in overweight PCOS adolescents (OR: 1·270, 95% CI: 1·174–1·374).
Conclusion
In conclusion, we suggest that increased LAP index and decreased total thiol levels may contribute to the increased CVD risk in overweight adolescents with PCOS.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>26492953</pmid><doi>10.1111/cen.12965</doi><tpages>8</tpages></addata></record> |
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subjects | Adolescent Cardiovascular Diseases - blood Cardiovascular Diseases - diagnosis Cardiovascular Diseases - physiopathology Case-Control Studies Disulfides - blood Female Homeostasis Humans Lipids - blood Logistic Models Multivariate Analysis Obesity - blood Obesity - physiopathology Overweight - blood Overweight - physiopathology Polycystic Ovary Syndrome - blood Polycystic Ovary Syndrome - physiopathology Risk Assessment Risk Factors Sulfhydryl Compounds - blood |
title | The association of thiol/disulphide homeostasis and lipid accumulation index with cardiovascular risk factors in overweight adolescents with polycystic ovary syndrome |
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