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Algorithm that delivers an individualized rapid-acting insulin dose after morning resistance exercise counters post-exercise hyperglycaemia in people with Type 1 diabetes
Aims To develop an algorithm that delivers an individualized dose of rapid‐acting insulin after morning resistance exercise to counter post‐exercise hyperglycaemia in individuals with Type 1 diabetes. Methods Eight people with Type 1 diabetes, aged 34 ± 7 years with HbA1c concentrations 72 ± 12 mmol...
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| Published in: | Diabetic medicine 2016-04, Vol.33 (4), p.506-510 |
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| container_end_page | 510 |
| container_issue | 4 |
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| container_title | Diabetic medicine |
| container_volume | 33 |
| creator | Turner, D. Luzio, S. Gray, B. J. Bain, S. C. Hanley, S. Richards, A. Rhydderch, D. C. Martin, R. Campbell, M. D. Kilduff, L. P. West, D. J. Bracken, R. M. |
| description | Aims
To develop an algorithm that delivers an individualized dose of rapid‐acting insulin after morning resistance exercise to counter post‐exercise hyperglycaemia in individuals with Type 1 diabetes.
Methods
Eight people with Type 1 diabetes, aged 34 ± 7 years with HbA1c concentrations 72 ± 12 mmol/mol (8.7 ± 1.1%), attended our laboratory on two separate mornings after fasting, having taken their usual basal insulin the previous evening. These people performed a resistance exercise session comprising six exercises for two sets of 10 repetitions at 60% of the maximum amount of force that was generated in one maximal contraction (60% 1RM). In a randomized and counterbalanced order, the participants were administered an individualized dose of rapid‐acting insulin (2 ± 1 units, range 0–4 units) immediately after resistance exercise (insulin session) by means of an algorithm or were not administered this (no‐insulin session). Venous blood glucose concentrations were measured for 125 min after resistance exercise. Data (mean ± sem values) were analysed using anova (P ≤ 0.05).
Results
Participants had immediate post‐resistance exercise hyperglycaemia (insulin session 13.0 ± 1.6 vs. no‐insulin session 12.7 ± 1.5 mmol/l; P = 0.834). The decline in blood glucose concentration between peak and 125 min after exercise was greater in the insulin exercise session than in the no‐insulin session (3.3 ± 1.0 vs. 1.3 ± 0.4 mmol/l: P = 0.015). There were no episodes of hypoglycaemia (blood glucose |
| doi_str_mv | 10.1111/dme.12870 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1897369614</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1775169844</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4940-4b818b7e9ec84725bc771c5aa4d446facf274d05e5ed042655d78ead4a2946f43</originalsourceid><addsrcrecordid>eNqNkc1u1DAURi0EotOBBS-ALLGhi7S248TxsiqlIJVhQRFSN5Zj38y4OD_YSdvhkXhKHKadBRIS3ljyd-7RtT6EXlFyTNM5sS0cU1YJ8gQtKC95VnBJn6IFEZxlORH0AB3GeEMIZTKXz9EBKxkjlMsF-nXq131w46bF40aP2IJ3txAi1h12nXW3zk7au59gcdCDs5k2o-vWKYuTdx22fQSsmxECbvvQzVGA6OKoOwMY7iEYlwjTT904a4c-jtn-ebMdIKz91mhonU5SPEA_eMB3aSN8lVJMsXW6hhHiC_Ss0T7Cy4d7ib6-P786-5Bdfr74eHZ6mRkuOcl4XdGqFiDBVFywojZCUFNozS3nZaNNwwS3pIACLOGsLAorKtCWayZTzvMlervzDqH_MUEcVeuiAe91B_0UFa2kyEtZ0v9AhShoKSs-o2_-Qm_6KXTpIzPF80qWSbtERzvKhD7GAI0agmt12CpK1Ny1Sl2rP10n9vWDcapbsHvysdwEnOyAO-dh-2-Tevfp_FGZ7SZSgXC_n9DhuypFLgr1bXWhVte5rNiXlbrOfwN_KsWF</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1774389697</pqid></control><display><type>article</type><title>Algorithm that delivers an individualized rapid-acting insulin dose after morning resistance exercise counters post-exercise hyperglycaemia in people with Type 1 diabetes</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Turner, D. ; Luzio, S. ; Gray, B. J. ; Bain, S. C. ; Hanley, S. ; Richards, A. ; Rhydderch, D. C. ; Martin, R. ; Campbell, M. D. ; Kilduff, L. P. ; West, D. J. ; Bracken, R. M.</creator><creatorcontrib>Turner, D. ; Luzio, S. ; Gray, B. J. ; Bain, S. C. ; Hanley, S. ; Richards, A. ; Rhydderch, D. C. ; Martin, R. ; Campbell, M. D. ; Kilduff, L. P. ; West, D. J. ; Bracken, R. M.</creatorcontrib><description>Aims
To develop an algorithm that delivers an individualized dose of rapid‐acting insulin after morning resistance exercise to counter post‐exercise hyperglycaemia in individuals with Type 1 diabetes.
Methods
Eight people with Type 1 diabetes, aged 34 ± 7 years with HbA1c concentrations 72 ± 12 mmol/mol (8.7 ± 1.1%), attended our laboratory on two separate mornings after fasting, having taken their usual basal insulin the previous evening. These people performed a resistance exercise session comprising six exercises for two sets of 10 repetitions at 60% of the maximum amount of force that was generated in one maximal contraction (60% 1RM). In a randomized and counterbalanced order, the participants were administered an individualized dose of rapid‐acting insulin (2 ± 1 units, range 0–4 units) immediately after resistance exercise (insulin session) by means of an algorithm or were not administered this (no‐insulin session). Venous blood glucose concentrations were measured for 125 min after resistance exercise. Data (mean ± sem values) were analysed using anova (P ≤ 0.05).
Results
Participants had immediate post‐resistance exercise hyperglycaemia (insulin session 13.0 ± 1.6 vs. no‐insulin session 12.7 ± 1.5 mmol/l; P = 0.834). The decline in blood glucose concentration between peak and 125 min after exercise was greater in the insulin exercise session than in the no‐insulin session (3.3 ± 1.0 vs. 1.3 ± 0.4 mmol/l: P = 0.015). There were no episodes of hypoglycaemia (blood glucose <3.9 mmol/l).
Conclusions
Administration of rapid‐acting insulin according to an individualized algorithm reduced the hyperglycaemia associated with morning resistance exercise without causing hypoglycaemia in the 2 h post‐exercise period in people with Type 1 diabetes.
What's new?
Regular performance of resistance exercise can improve the health and well‐being of people with Type 1 diabetes, but there is currently no systematic and/or validated method of correcting the post‐exercise hyperglycaemia associated with acute resistance exercise, leaving people with Type 1 diabetes vulnerable to poor glycaemic control.
The results from the present study show that the administration of a single dose of a rapid‐acting insulin analogue, calculated using a simple algorithm, can reduce the amount of post‐exercise hyperglycaemia occurring after morning resistance exercise in people with Type 1 diabetes, without causing early post‐exercise hypoglycaemia.</description><identifier>ISSN: 0742-3071</identifier><identifier>EISSN: 1464-5491</identifier><identifier>DOI: 10.1111/dme.12870</identifier><identifier>PMID: 26220149</identifier><identifier>CODEN: DIMEEV</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject><![CDATA[Adult ; Algorithms ; Blood Glucose - analysis ; Combined Modality Therapy ; Diabetes ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - drug therapy ; Diabetes Mellitus, Type 1 - therapy ; Drug Administration Schedule ; Drug Dosage Calculations ; Drug Monitoring ; Drug Therapy, Combination - adverse effects ; Glucose ; Humans ; Hyperglycemia ; Hyperglycemia - epidemiology ; Hyperglycemia - etiology ; Hyperglycemia - prevention & control ; Hypoglycemia ; Hypoglycemia - chemically induced ; Hypoglycemia - prevention & control ; Hypoglycemic Agents - administration & dosage ; Hypoglycemic Agents - adverse effects ; Hypoglycemic Agents - therapeutic use ; Insulin ; Insulin Aspart - administration & dosage ; Insulin Aspart - adverse effects ; Insulin Aspart - therapeutic use ; Insulin Detemir - administration & dosage ; Insulin Detemir - adverse effects ; Insulin Detemir - therapeutic use ; Insulin Glargine - administration & dosage ; Insulin Glargine - adverse effects ; Insulin Glargine - therapeutic use ; Pilot Projects ; Precision Medicine ; Resistance Training - adverse effects ; Risk ; United Kingdom - epidemiology]]></subject><ispartof>Diabetic medicine, 2016-04, Vol.33 (4), p.506-510</ispartof><rights>2015 Diabetes UK</rights><rights>2015 Diabetes UK.</rights><rights>Diabetic Medicine © 2016 Diabetes UK</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4940-4b818b7e9ec84725bc771c5aa4d446facf274d05e5ed042655d78ead4a2946f43</citedby><cites>FETCH-LOGICAL-c4940-4b818b7e9ec84725bc771c5aa4d446facf274d05e5ed042655d78ead4a2946f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26220149$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Turner, D.</creatorcontrib><creatorcontrib>Luzio, S.</creatorcontrib><creatorcontrib>Gray, B. J.</creatorcontrib><creatorcontrib>Bain, S. C.</creatorcontrib><creatorcontrib>Hanley, S.</creatorcontrib><creatorcontrib>Richards, A.</creatorcontrib><creatorcontrib>Rhydderch, D. C.</creatorcontrib><creatorcontrib>Martin, R.</creatorcontrib><creatorcontrib>Campbell, M. D.</creatorcontrib><creatorcontrib>Kilduff, L. P.</creatorcontrib><creatorcontrib>West, D. J.</creatorcontrib><creatorcontrib>Bracken, R. M.</creatorcontrib><title>Algorithm that delivers an individualized rapid-acting insulin dose after morning resistance exercise counters post-exercise hyperglycaemia in people with Type 1 diabetes</title><title>Diabetic medicine</title><addtitle>Diabet. Med</addtitle><description>Aims
To develop an algorithm that delivers an individualized dose of rapid‐acting insulin after morning resistance exercise to counter post‐exercise hyperglycaemia in individuals with Type 1 diabetes.
Methods
Eight people with Type 1 diabetes, aged 34 ± 7 years with HbA1c concentrations 72 ± 12 mmol/mol (8.7 ± 1.1%), attended our laboratory on two separate mornings after fasting, having taken their usual basal insulin the previous evening. These people performed a resistance exercise session comprising six exercises for two sets of 10 repetitions at 60% of the maximum amount of force that was generated in one maximal contraction (60% 1RM). In a randomized and counterbalanced order, the participants were administered an individualized dose of rapid‐acting insulin (2 ± 1 units, range 0–4 units) immediately after resistance exercise (insulin session) by means of an algorithm or were not administered this (no‐insulin session). Venous blood glucose concentrations were measured for 125 min after resistance exercise. Data (mean ± sem values) were analysed using anova (P ≤ 0.05).
Results
Participants had immediate post‐resistance exercise hyperglycaemia (insulin session 13.0 ± 1.6 vs. no‐insulin session 12.7 ± 1.5 mmol/l; P = 0.834). The decline in blood glucose concentration between peak and 125 min after exercise was greater in the insulin exercise session than in the no‐insulin session (3.3 ± 1.0 vs. 1.3 ± 0.4 mmol/l: P = 0.015). There were no episodes of hypoglycaemia (blood glucose <3.9 mmol/l).
Conclusions
Administration of rapid‐acting insulin according to an individualized algorithm reduced the hyperglycaemia associated with morning resistance exercise without causing hypoglycaemia in the 2 h post‐exercise period in people with Type 1 diabetes.
What's new?
Regular performance of resistance exercise can improve the health and well‐being of people with Type 1 diabetes, but there is currently no systematic and/or validated method of correcting the post‐exercise hyperglycaemia associated with acute resistance exercise, leaving people with Type 1 diabetes vulnerable to poor glycaemic control.
The results from the present study show that the administration of a single dose of a rapid‐acting insulin analogue, calculated using a simple algorithm, can reduce the amount of post‐exercise hyperglycaemia occurring after morning resistance exercise in people with Type 1 diabetes, without causing early post‐exercise hypoglycaemia.</description><subject>Adult</subject><subject>Algorithms</subject><subject>Blood Glucose - analysis</subject><subject>Combined Modality Therapy</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - drug therapy</subject><subject>Diabetes Mellitus, Type 1 - therapy</subject><subject>Drug Administration Schedule</subject><subject>Drug Dosage Calculations</subject><subject>Drug Monitoring</subject><subject>Drug Therapy, Combination - adverse effects</subject><subject>Glucose</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Hyperglycemia - epidemiology</subject><subject>Hyperglycemia - etiology</subject><subject>Hyperglycemia - prevention & control</subject><subject>Hypoglycemia</subject><subject>Hypoglycemia - chemically induced</subject><subject>Hypoglycemia - prevention & control</subject><subject>Hypoglycemic Agents - administration & dosage</subject><subject>Hypoglycemic Agents - adverse effects</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Insulin</subject><subject>Insulin Aspart - administration & dosage</subject><subject>Insulin Aspart - adverse effects</subject><subject>Insulin Aspart - therapeutic use</subject><subject>Insulin Detemir - administration & dosage</subject><subject>Insulin Detemir - adverse effects</subject><subject>Insulin Detemir - therapeutic use</subject><subject>Insulin Glargine - administration & dosage</subject><subject>Insulin Glargine - adverse effects</subject><subject>Insulin Glargine - therapeutic use</subject><subject>Pilot Projects</subject><subject>Precision Medicine</subject><subject>Resistance Training - adverse effects</subject><subject>Risk</subject><subject>United Kingdom - epidemiology</subject><issn>0742-3071</issn><issn>1464-5491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkc1u1DAURi0EotOBBS-ALLGhi7S248TxsiqlIJVhQRFSN5Zj38y4OD_YSdvhkXhKHKadBRIS3ljyd-7RtT6EXlFyTNM5sS0cU1YJ8gQtKC95VnBJn6IFEZxlORH0AB3GeEMIZTKXz9EBKxkjlMsF-nXq131w46bF40aP2IJ3txAi1h12nXW3zk7au59gcdCDs5k2o-vWKYuTdx22fQSsmxECbvvQzVGA6OKoOwMY7iEYlwjTT904a4c-jtn-ebMdIKz91mhonU5SPEA_eMB3aSN8lVJMsXW6hhHiC_Ss0T7Cy4d7ib6-P786-5Bdfr74eHZ6mRkuOcl4XdGqFiDBVFywojZCUFNozS3nZaNNwwS3pIACLOGsLAorKtCWayZTzvMlervzDqH_MUEcVeuiAe91B_0UFa2kyEtZ0v9AhShoKSs-o2_-Qm_6KXTpIzPF80qWSbtERzvKhD7GAI0agmt12CpK1Ny1Sl2rP10n9vWDcapbsHvysdwEnOyAO-dh-2-Tevfp_FGZ7SZSgXC_n9DhuypFLgr1bXWhVte5rNiXlbrOfwN_KsWF</recordid><startdate>201604</startdate><enddate>201604</enddate><creator>Turner, D.</creator><creator>Luzio, S.</creator><creator>Gray, B. J.</creator><creator>Bain, S. C.</creator><creator>Hanley, S.</creator><creator>Richards, A.</creator><creator>Rhydderch, D. C.</creator><creator>Martin, R.</creator><creator>Campbell, M. D.</creator><creator>Kilduff, L. P.</creator><creator>West, D. J.</creator><creator>Bracken, R. M.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>201604</creationdate><title>Algorithm that delivers an individualized rapid-acting insulin dose after morning resistance exercise counters post-exercise hyperglycaemia in people with Type 1 diabetes</title><author>Turner, D. ; Luzio, S. ; Gray, B. J. ; Bain, S. C. ; Hanley, S. ; Richards, A. ; Rhydderch, D. C. ; Martin, R. ; Campbell, M. D. ; Kilduff, L. P. ; West, D. J. ; Bracken, R. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4940-4b818b7e9ec84725bc771c5aa4d446facf274d05e5ed042655d78ead4a2946f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Algorithms</topic><topic>Blood Glucose - analysis</topic><topic>Combined Modality Therapy</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 1 - drug therapy</topic><topic>Diabetes Mellitus, Type 1 - therapy</topic><topic>Drug Administration Schedule</topic><topic>Drug Dosage Calculations</topic><topic>Drug Monitoring</topic><topic>Drug Therapy, Combination - adverse effects</topic><topic>Glucose</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Hyperglycemia - epidemiology</topic><topic>Hyperglycemia - etiology</topic><topic>Hyperglycemia - prevention & control</topic><topic>Hypoglycemia</topic><topic>Hypoglycemia - chemically induced</topic><topic>Hypoglycemia - prevention & control</topic><topic>Hypoglycemic Agents - administration & dosage</topic><topic>Hypoglycemic Agents - adverse effects</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Insulin</topic><topic>Insulin Aspart - administration & dosage</topic><topic>Insulin Aspart - adverse effects</topic><topic>Insulin Aspart - therapeutic use</topic><topic>Insulin Detemir - administration & dosage</topic><topic>Insulin Detemir - adverse effects</topic><topic>Insulin Detemir - therapeutic use</topic><topic>Insulin Glargine - administration & dosage</topic><topic>Insulin Glargine - adverse effects</topic><topic>Insulin Glargine - therapeutic use</topic><topic>Pilot Projects</topic><topic>Precision Medicine</topic><topic>Resistance Training - adverse effects</topic><topic>Risk</topic><topic>United Kingdom - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Turner, D.</creatorcontrib><creatorcontrib>Luzio, S.</creatorcontrib><creatorcontrib>Gray, B. J.</creatorcontrib><creatorcontrib>Bain, S. C.</creatorcontrib><creatorcontrib>Hanley, S.</creatorcontrib><creatorcontrib>Richards, A.</creatorcontrib><creatorcontrib>Rhydderch, D. C.</creatorcontrib><creatorcontrib>Martin, R.</creatorcontrib><creatorcontrib>Campbell, M. D.</creatorcontrib><creatorcontrib>Kilduff, L. P.</creatorcontrib><creatorcontrib>West, D. J.</creatorcontrib><creatorcontrib>Bracken, R. M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>Diabetic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Turner, D.</au><au>Luzio, S.</au><au>Gray, B. J.</au><au>Bain, S. C.</au><au>Hanley, S.</au><au>Richards, A.</au><au>Rhydderch, D. C.</au><au>Martin, R.</au><au>Campbell, M. D.</au><au>Kilduff, L. P.</au><au>West, D. J.</au><au>Bracken, R. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Algorithm that delivers an individualized rapid-acting insulin dose after morning resistance exercise counters post-exercise hyperglycaemia in people with Type 1 diabetes</atitle><jtitle>Diabetic medicine</jtitle><addtitle>Diabet. Med</addtitle><date>2016-04</date><risdate>2016</risdate><volume>33</volume><issue>4</issue><spage>506</spage><epage>510</epage><pages>506-510</pages><issn>0742-3071</issn><eissn>1464-5491</eissn><coden>DIMEEV</coden><abstract>Aims
To develop an algorithm that delivers an individualized dose of rapid‐acting insulin after morning resistance exercise to counter post‐exercise hyperglycaemia in individuals with Type 1 diabetes.
Methods
Eight people with Type 1 diabetes, aged 34 ± 7 years with HbA1c concentrations 72 ± 12 mmol/mol (8.7 ± 1.1%), attended our laboratory on two separate mornings after fasting, having taken their usual basal insulin the previous evening. These people performed a resistance exercise session comprising six exercises for two sets of 10 repetitions at 60% of the maximum amount of force that was generated in one maximal contraction (60% 1RM). In a randomized and counterbalanced order, the participants were administered an individualized dose of rapid‐acting insulin (2 ± 1 units, range 0–4 units) immediately after resistance exercise (insulin session) by means of an algorithm or were not administered this (no‐insulin session). Venous blood glucose concentrations were measured for 125 min after resistance exercise. Data (mean ± sem values) were analysed using anova (P ≤ 0.05).
Results
Participants had immediate post‐resistance exercise hyperglycaemia (insulin session 13.0 ± 1.6 vs. no‐insulin session 12.7 ± 1.5 mmol/l; P = 0.834). The decline in blood glucose concentration between peak and 125 min after exercise was greater in the insulin exercise session than in the no‐insulin session (3.3 ± 1.0 vs. 1.3 ± 0.4 mmol/l: P = 0.015). There were no episodes of hypoglycaemia (blood glucose <3.9 mmol/l).
Conclusions
Administration of rapid‐acting insulin according to an individualized algorithm reduced the hyperglycaemia associated with morning resistance exercise without causing hypoglycaemia in the 2 h post‐exercise period in people with Type 1 diabetes.
What's new?
Regular performance of resistance exercise can improve the health and well‐being of people with Type 1 diabetes, but there is currently no systematic and/or validated method of correcting the post‐exercise hyperglycaemia associated with acute resistance exercise, leaving people with Type 1 diabetes vulnerable to poor glycaemic control.
The results from the present study show that the administration of a single dose of a rapid‐acting insulin analogue, calculated using a simple algorithm, can reduce the amount of post‐exercise hyperglycaemia occurring after morning resistance exercise in people with Type 1 diabetes, without causing early post‐exercise hypoglycaemia.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>26220149</pmid><doi>10.1111/dme.12870</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0742-3071 |
| ispartof | Diabetic medicine, 2016-04, Vol.33 (4), p.506-510 |
| issn | 0742-3071 1464-5491 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1897369614 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adult Algorithms Blood Glucose - analysis Combined Modality Therapy Diabetes Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - therapy Drug Administration Schedule Drug Dosage Calculations Drug Monitoring Drug Therapy, Combination - adverse effects Glucose Humans Hyperglycemia Hyperglycemia - epidemiology Hyperglycemia - etiology Hyperglycemia - prevention & control Hypoglycemia Hypoglycemia - chemically induced Hypoglycemia - prevention & control Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - adverse effects Hypoglycemic Agents - therapeutic use Insulin Insulin Aspart - administration & dosage Insulin Aspart - adverse effects Insulin Aspart - therapeutic use Insulin Detemir - administration & dosage Insulin Detemir - adverse effects Insulin Detemir - therapeutic use Insulin Glargine - administration & dosage Insulin Glargine - adverse effects Insulin Glargine - therapeutic use Pilot Projects Precision Medicine Resistance Training - adverse effects Risk United Kingdom - epidemiology |
| title | Algorithm that delivers an individualized rapid-acting insulin dose after morning resistance exercise counters post-exercise hyperglycaemia in people with Type 1 diabetes |
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