Fitness during Breast Cancer Treatment and Recovery in an Athlete: A Case Study

• Published in: Medicine and science in sports and exercise 2016-10, Vol.48 (10), p.1893-1897
• Main Authors: SAVAGE, PATRICK D, DITTUS, KIM, LAKOSKI, SUSAN G
• Format: Article
• Language: English
• Subjects: Adult; Antineoplastic Agents - therapeutic use; Breast Neoplasms - physiopathology; Breast Neoplasms - therapy; Cardiorespiratory Fitness; Exercise Tolerance - physiology; Female; Humans; Mastectomy; Radiotherapy, Adjuvant
• ISSN: 0195-9131; 1530-0315
• DOI: 10.1249/MSS.0000000000000987

PURPOSEThis is a case study of an aerobically trained, multisport, female athlete (age = 39) diagnosed with stage IIIc human epidermal growth factor receptor 2 positive breast cancer. The focus of the study is on measures of cardiorespiratory fitness (V˙O2peak) through the course of cancer therapy. METHODSA symptom-limited cardiopulmonary exercise tolerance test was performed to determine V˙O2peak. The tests were performed at five different time points1) at diagnosis of breast cancer and before initiating chemotherapy, 2) after completion of chemotherapy (5 months postdiagnosis), 3) 2.5 months after bilateral mastectomy surgery (9 months postdiagnosis), 4) immediately after radiation therapy (11 months postdiagnosis), and 5) recovery (32 months postdiagnosis). RESULTSAt diagnosis and before initiating chemotherapy, V˙O2peak was 50.1 mL O2·min·kg. The most precipitous decline in fitness, approximately 14%, was observed from initial diagnosis through the completion of chemotherapy. The subject regained 9% of her fitness after chemotherapy, despite an intervening mastectomy surgery. Radiation therapy was associated with an approximately 4% decline in fitness from her postmastectomy surgery value. Ultimately, 32 months after diagnosis and 22 months after the completion of radiation therapy, the subject was able to regain pretreatment fitness levels. CONCLUSIONThe results of the case study describe the effects of undergoing extensive breast cancer therapy on measures of V˙O2peak for a highly aerobically trained, multisport athlete. In this case, exercise training reversed the decrement in measured V˙O2peak that occurred during cancer therapy.