The Many Faces of Asthma in Obesity

ABSTRACT Obesity is a major risk factor for the development of asthma, and causes severe, uncontrolled disease that responds poorly to therapy. The obese state alters early onset allergic asthma, and leads to the development of a novel form of late onset asthma secondary to obesity. The presentation...

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Bibliographic Details
Published in:Journal of cellular biochemistry 2014-03, Vol.115 (3), p.421-426
Main Authors: Sideleva, O., Dixon, A.E.
Format: Article
Language:English
Subjects:
ADIPOKINES
Adipokines - metabolism
Age of Onset
AIRWAY REACTIVITY
ASTHMA
Asthma - complications
Asthma - pathology
Asthma - therapy
Diet
Humans
Hypersensitivity - complications
Hypersensitivity - pathology
Insulin Resistance - genetics
Nitric Oxide - metabolism
OBESITY
Obesity - complications
Obesity - pathology
Obesity - therapy
Ozone - metabolism
Risk Factors
Weight Loss
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Summary:ABSTRACT Obesity is a major risk factor for the development of asthma, and causes severe, uncontrolled disease that responds poorly to therapy. The obese state alters early onset allergic asthma, and leads to the development of a novel form of late onset asthma secondary to obesity. The presentation of early onset allergic asthma is altered through effects on immune function. Factors such as mechanical loading, effects of adipokines on airways, altered diet, insulin resistance and altered metabolism of nitric oxide likely all contribute to increased airway reactivity in obesity, causing late onset asthma in obesity. Obesity also alters responses to environmental factors such as ozone and particulate matter. Focused studies to understand the importance of these factors in the pathogenesis of airway disease in obesity will be essential to develop therapies to intervene in this new epidemic of airway disease. J. Cell. Biochem. 115: 421–426, 2014. © 2013 Wiley Periodicals, Inc.
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.24678