Short sleep duration and obesity: mechanisms and future perspectives

A reduction of sleep time has become common over the last century, and growing evidence from both epidemiological and laboratory‐based studies suggests sleep curtailment is a new risk factor for the development of obesity. On this basis, the present review examines the role of sleep curtailment in t...

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Bibliographic Details
Published in:Cell biochemistry and function 2012-08, Vol.30 (6), p.524-529
Main Authors: Zimberg, Ioná Zalcman, Dâmaso, Ana, Del Re, Mariana, Carneiro, Aline Millani, de Sá Souza, Helton, de Lira, Fábio Santos, Tufik, Sergio, de Mello, Marco Túlio
Format: Article
Language:English
Subjects:
Animals
diabetes
hormones
Humans
nutrition
obesity
Obesity - epidemiology
Obesity - etiology
Obesity - metabolism
Risk Factors
sleep
Sleep Deprivation - complications
Sleep Deprivation - epidemiology
Sleep Deprivation - metabolism
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Summary:A reduction of sleep time has become common over the last century, and growing evidence from both epidemiological and laboratory‐based studies suggests sleep curtailment is a new risk factor for the development of obesity. On this basis, the present review examines the role of sleep curtailment in the metabolic and endocrine alterations, including decreased glucose tolerance and insulin sensitivity, increased evening concentrations of cortisol, increased levels of ghrelin, decreased levels of leptin and increased hunger and appetite. It will be discussed how sleep restriction may lead to increase in food intake and result in greater fatigue, which may favour decreased energy expenditure. Altogether, evidences point to a possible role of decreased sleep duration in the current epidemic of obesity and therefore present literature highlights the importance of getting enough good sleep for metabolic health. Many aspects still need to be clarified and intervention studies also need to be conducted. Copyright © 2012 John Wiley & Sons, Ltd.
ISSN:0263-6484
1099-0844
DOI:10.1002/cbf.2832