Current evidence that exercise can increase the number of adult stem cells

The number of adult stem cells (ASCs) is very small, limiting the regenerative potential of tissues. One of the most studied ASCs in humans is the satellite cell (SC), which proliferates and increases pool size under exercise stress and muscle damage. This review examines the growth factor response...

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Bibliographic Details
Published in:Journal of muscle research and cell motility 2012-08, Vol.33 (3-4), p.187-198
Main Authors: Macaluso, F., Myburgh, K. H.
Format: Article
Language:English
Subjects:
Adult Stem Cells - cytology
Animal Anatomy
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell Growth Processes - physiology
EMC2012 Special Issue - Original Paper
Exercise - physiology
Histology
Humans
Life Sciences
Morphology
Proteomics
Resistance Training
Stem Cell Niche - physiology
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Summary:The number of adult stem cells (ASCs) is very small, limiting the regenerative potential of tissues. One of the most studied ASCs in humans is the satellite cell (SC), which proliferates and increases pool size under exercise stress and muscle damage. This review examines the growth factor response to specific types of exercise to show the potential of exercise to stimulate not only SC self-renewal, but also other ASCs. We postulate that the same factors that stimulate a high proliferation of SCs in skeletal muscle after physical exercise should also stimulate the proliferation of ASCs in the tissue in which they reside, such as heart, bone, liver and etc. Regular exercise should be promoted, not only for disease prevention, but to maintain a high ASCs reserve and progenitor cell potential for rapid activation in response to future stressors and damage.
ISSN:0142-4319
1573-2657
DOI:10.1007/s10974-012-9302-0