Clinical utility of spot urine protein-to-creatinine ratio modified by estimated daily creatinine excretion in children

Background The spot urine protein-to-creatinine ratio (UPCR) is widely used to predict 24-h urine protein (24-h UP) excretion. In patients with low daily urine creatinine excretion (UCr), however, the UPCR may overestimate 24-h UP. The aim of this study was to predict 24-h UP using UPCR adjusted by...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2017-06, Vol.32 (6), p.1045-1051
Main Authors: Yang, Eun Mi, Yoon, Bo Ae, Kim, Soo Wan, Kim, Chan Jong
Format: Article
Language:English
Subjects:
Accuracy
Adolescent
Child
Child, Preschool
Creatinine
Creatinine - metabolism
Creatinine - urine
Female
Humans
Infant
Kidney Function Tests - methods
Male
Medical records
Medicine
Medicine & Public Health
Nephrology
Original Article
Patients
Pediatrics
Proteins
Proteinuria - metabolism
Proteinuria - urine
Renal Elimination
Retrospective Studies
Urine
Urology
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Summary:Background The spot urine protein-to-creatinine ratio (UPCR) is widely used to predict 24-h urine protein (24-h UP) excretion. In patients with low daily urine creatinine excretion (UCr), however, the UPCR may overestimate 24-h UP. The aim of this study was to predict 24-h UP using UPCR adjusted by estimated 24-h UCr in children. Methods This study included 442 children whose 24-h UP and spot UPCR were measured concomitantly. Estimated 24-h UCr was calculated using three previously existing equations. We estimated the 24-h UP excretion from UPCR by multiplying the estimated UCr. The results were compared with the measured 24-h UP. Results There was a strong correlation between UPCR and 24-h UP ( r  = 0.801, P  
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-017-3587-6