Neural correlates of the popular music phenomenon: evidence from functional MRI and PET imaging

• Published in: European journal of nuclear medicine and molecular imaging 2017-06, Vol.44 (6), p.1033-1041
• Main Authors: Chen, Qiaozhen, Zhang, Ying, Hou, Haifeng, Du, Fenglei, Wu, Shuang, Chen, Lin, Shen, Yehua, Chao, Fangfang, Chung, June-key, Zhang, Hong, Tian, Mei
• Format: Article
• Language: English
• Subjects: Adult; Brain; Brain Mapping; Carbon Radioisotopes; Cardiology; Emotions; Healthy Volunteers; Humans; Imaging; Magnetic Resonance Imaging; Male; Medicine; Medicine & Public Health; Multimodal Imaging; Music; NMR; Nuclear magnetic resonance; Nuclear Medicine; Oncology; Original Article; Orthopedics; Radiology; Spiperone - analogs & derivatives; Tomography; Tomography, X-Ray Computed; Young Adult
• ISSN: 1619-7070; 1619-7089
• DOI: 10.1007/s00259-017-3614-7

Purpose Music can induce different emotions. However, its neural mechanism remains unknown. The aim of this study was to use functional magnetic resonance imaging (fMRI) and position emission tomography (PET) imaging for mapping of neural changes under the most popular music in healthy volunteers. Methods Blood-oxygen-level-dependent (BOLD) fMRI and monoamine receptor PET imaging with 11 C-N-methylspiperone ( 11 C-NMSP) were conducted under the popular music Gangnam Style and light music A Comme Amour in healthy subjects. PET and fMRI images were analyzed by using the Statistical Parametric Mapping software (SPM). Results Significantly increased fMRI BOLD signals were found in the bilateral superior temporal cortices, left cerebellum, left putamen and right thalamus cortex. Monoamine receptor availability was increased significantly in the left superior temporal gyrus and left putamen, but decreased in the bilateral superior occipital cortices under the Gangnam Style compared with the light music condition. Significant positive correlation was found between 11 C-NMSP binding and fMRI BOLD signals in the left temporal cortex. Furthermore, increased 11 C-NMSP binding in the left putamen was positively correlated with the mood arousal level score under the Gangnam Style condition. Conclusion Popular music Gangnam Style can arouse pleasure experience and strong emotional response. The left putamen is positively correlated with the mood arousal level score under the Gangnam Style condition. Our results revealed characteristic patterns of brain activity associated with Gangnam Style, and may also provide more general insights into the music-induced emotional processing.