Effects of supervised exercise on progression-free survival in lymphoma patients: an exploratory follow-up of the HELP Trial

Purpose: Few randomized controlled trials in exercise oncology have examined survival outcomes. Here, we report an exploratory follow-up of progression-free survival (PFS) from the H̱ealthy E̱xercise for Ḻymphoma P̱atients (HELP) Trial. Methods: The HELP Trial randomized 122 lymphoma patients betwee...

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Published in:Cancer causes & control 2015-02, Vol.26 (2), p.269-276
Main Authors: Courneya, Kerry S., Friedenreich, Christine M., Franco-Villalobos, Conrado, Crawford, Jennifer J., Chua, Neil, Basi, Sanraj, Norris, Mary K., Reiman, Tony
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aerobics
Aged
Aged, 80 and over
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cancer therapies
Chemotherapy
Combined Modality Therapy
Cross-Over Studies
Disease-Free Survival
Epidemiology
Exercise
Exercise Therapy - methods
Female
Follow-Up Studies
Health care
Hematology
Humans
Lymphoma
Lymphoma - therapy
Male
Middle Aged
Oncology
Original Paper
Patients
Physical fitness
Public Health
Quality of life
Time Factors
Treatment Outcome
Young Adult
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container_title Cancer causes & control
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creator Courneya, Kerry S.
Friedenreich, Christine M.
Franco-Villalobos, Conrado
Crawford, Jennifer J.
Chua, Neil
Basi, Sanraj
Norris, Mary K.
Reiman, Tony
description Purpose: Few randomized controlled trials in exercise oncology have examined survival outcomes. Here, we report an exploratory follow-up of progression-free survival (PFS) from the H̱ealthy E̱xercise for Ḻymphoma P̱atients (HELP) Trial. Methods: The HELP Trial randomized 122 lymphoma patients between 2005 and 2008 to either control (n = 62) or 12 weeks of supervised aerobic exercise (n = 60). PFS events were abstracted from medical records in 2013. In addition to the randomized comparison, we explored the effects of exercise adherence (
doi_str_mv 10.1007/s10552-014-0508-x
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Here, we report an exploratory follow-up of progression-free survival (PFS) from the H̱ealthy E̱xercise for Ḻymphoma P̱atients (HELP) Trial. Methods: The HELP Trial randomized 122 lymphoma patients between 2005 and 2008 to either control (n = 62) or 12 weeks of supervised aerobic exercise (n = 60). PFS events were abstracted from medical records in 2013. In addition to the randomized comparison, we explored the effects of exercise adherence (&lt;80 % vs. ≥80 %) and control group crossover (no vs. yes). Results: After a median follow-up of 61 months (interquartile range 36–67), the adjusted 5-year PFS was 64.8 % for the exercise group compared with 65.0 % for the control group (Hazard ratio [HR] 1.01, 95 % CI 0.51–2.01, p = 0.98). In the secondary analysis, the adjusted 5-year PFS was 59.0 % in the control group without crossover compared with 69.2 % for the control group with crossover (HR 0.68, 95 % CI 0.22–2.06, p = 0.49), 67.7 % for the exercise group with &lt;80 % adherence (HR 0.72, 95 % CI 0.28–1.85, p = 0.50), and 68.4 % for the exercise group with ≥80 % adherence (HR 0.70, 95 % CI 0.32–1.56, p = 0.39). In a post hoc analysis combining the three groups that received supervised exercise, the adjusted 5-year PFS for the supervised exercise groups was 68.5 % compared with 59.0 % for the group that received no supervised exercise (HR 0.70, 95 % CI 0.35–1.39, p = 0.31). Conclusions: This exploratory follow-up of the HELP Trial suggests that supervised aerobic exercise may be associated with improved PFS in lymphoma patients. Larger trials designed to answer this question are needed.</description><identifier>ISSN: 0957-5243</identifier><identifier>EISSN: 1573-7225</identifier><identifier>DOI: 10.1007/s10552-014-0508-x</identifier><identifier>PMID: 25491935</identifier><identifier>CODEN: CCCNEN</identifier><language>eng</language><publisher>Cham: Springer</publisher><subject>Adolescent ; Adult ; Aerobics ; Aged ; Aged, 80 and over ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Cancer therapies ; Chemotherapy ; Combined Modality Therapy ; Cross-Over Studies ; Disease-Free Survival ; Epidemiology ; Exercise ; Exercise Therapy - methods ; Female ; Follow-Up Studies ; Health care ; Hematology ; Humans ; Lymphoma ; Lymphoma - therapy ; Male ; Middle Aged ; Oncology ; Original Paper ; Patients ; Physical fitness ; Public Health ; Quality of life ; Time Factors ; Treatment Outcome ; Young Adult</subject><ispartof>Cancer causes &amp; control, 2015-02, Vol.26 (2), p.269-276</ispartof><rights>2015 Springer International Publishing</rights><rights>Springer International Publishing Switzerland 2014</rights><rights>Springer International Publishing Switzerland 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c497t-45c11f53ed269e51508722c82f977aee3e14b7cfacbaf75309dae64d113d43933</citedby><cites>FETCH-LOGICAL-c497t-45c11f53ed269e51508722c82f977aee3e14b7cfacbaf75309dae64d113d43933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/24716162$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/24716162$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,58238,58471</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25491935$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Courneya, Kerry S.</creatorcontrib><creatorcontrib>Friedenreich, Christine M.</creatorcontrib><creatorcontrib>Franco-Villalobos, Conrado</creatorcontrib><creatorcontrib>Crawford, Jennifer J.</creatorcontrib><creatorcontrib>Chua, Neil</creatorcontrib><creatorcontrib>Basi, Sanraj</creatorcontrib><creatorcontrib>Norris, Mary K.</creatorcontrib><creatorcontrib>Reiman, Tony</creatorcontrib><title>Effects of supervised exercise on progression-free survival in lymphoma patients: an exploratory follow-up of the HELP Trial</title><title>Cancer causes &amp; control</title><addtitle>Cancer Causes Control</addtitle><addtitle>Cancer Causes Control</addtitle><description>Purpose: Few randomized controlled trials in exercise oncology have examined survival outcomes. Here, we report an exploratory follow-up of progression-free survival (PFS) from the H̱ealthy E̱xercise for Ḻymphoma P̱atients (HELP) Trial. Methods: The HELP Trial randomized 122 lymphoma patients between 2005 and 2008 to either control (n = 62) or 12 weeks of supervised aerobic exercise (n = 60). PFS events were abstracted from medical records in 2013. In addition to the randomized comparison, we explored the effects of exercise adherence (&lt;80 % vs. ≥80 %) and control group crossover (no vs. yes). Results: After a median follow-up of 61 months (interquartile range 36–67), the adjusted 5-year PFS was 64.8 % for the exercise group compared with 65.0 % for the control group (Hazard ratio [HR] 1.01, 95 % CI 0.51–2.01, p = 0.98). 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control</jtitle><stitle>Cancer Causes Control</stitle><addtitle>Cancer Causes Control</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>26</volume><issue>2</issue><spage>269</spage><epage>276</epage><pages>269-276</pages><issn>0957-5243</issn><eissn>1573-7225</eissn><coden>CCCNEN</coden><abstract>Purpose: Few randomized controlled trials in exercise oncology have examined survival outcomes. Here, we report an exploratory follow-up of progression-free survival (PFS) from the H̱ealthy E̱xercise for Ḻymphoma P̱atients (HELP) Trial. Methods: The HELP Trial randomized 122 lymphoma patients between 2005 and 2008 to either control (n = 62) or 12 weeks of supervised aerobic exercise (n = 60). PFS events were abstracted from medical records in 2013. In addition to the randomized comparison, we explored the effects of exercise adherence (&lt;80 % vs. ≥80 %) and control group crossover (no vs. yes). Results: After a median follow-up of 61 months (interquartile range 36–67), the adjusted 5-year PFS was 64.8 % for the exercise group compared with 65.0 % for the control group (Hazard ratio [HR] 1.01, 95 % CI 0.51–2.01, p = 0.98). In the secondary analysis, the adjusted 5-year PFS was 59.0 % in the control group without crossover compared with 69.2 % for the control group with crossover (HR 0.68, 95 % CI 0.22–2.06, p = 0.49), 67.7 % for the exercise group with &lt;80 % adherence (HR 0.72, 95 % CI 0.28–1.85, p = 0.50), and 68.4 % for the exercise group with ≥80 % adherence (HR 0.70, 95 % CI 0.32–1.56, p = 0.39). In a post hoc analysis combining the three groups that received supervised exercise, the adjusted 5-year PFS for the supervised exercise groups was 68.5 % compared with 59.0 % for the group that received no supervised exercise (HR 0.70, 95 % CI 0.35–1.39, p = 0.31). Conclusions: This exploratory follow-up of the HELP Trial suggests that supervised aerobic exercise may be associated with improved PFS in lymphoma patients. Larger trials designed to answer this question are needed.</abstract><cop>Cham</cop><pub>Springer</pub><pmid>25491935</pmid><doi>10.1007/s10552-014-0508-x</doi><tpages>8</tpages></addata></record>
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source JSTOR Archival Journals and Primary Sources Collection; Springer Link
subjects Adolescent
Adult
Aerobics
Aged
Aged, 80 and over
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cancer therapies
Chemotherapy
Combined Modality Therapy
Cross-Over Studies
Disease-Free Survival
Epidemiology
Exercise
Exercise Therapy - methods
Female
Follow-Up Studies
Health care
Hematology
Humans
Lymphoma
Lymphoma - therapy
Male
Middle Aged
Oncology
Original Paper
Patients
Physical fitness
Public Health
Quality of life
Time Factors
Treatment Outcome
Young Adult
title Effects of supervised exercise on progression-free survival in lymphoma patients: an exploratory follow-up of the HELP Trial
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