HHV8-related lymphoid proliferations: a broad spectrum of lesions from reactive lymphoid hyperplasia to overt lymphoma

Human herpesvirus 8 (HHV8)-associated lymphoid proliferations are uncommon and poorly characterized disorders mainly affecting immunosuppressed patients, especially with HIV infection. They encompass different diseases with overlapping features that complicate their classification. In addition, the...

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Bibliographic Details
Published in:Modern pathology 2017-05, Vol.30 (5), p.745-760
Main Authors: Gonzalez-Farre, Blanca, Martinez, Daniel, Lopez-Guerra, Monica, Xipell, Marc, Monclus, Ester, Rovira, Jordina, Garcia, Felipe, Lopez-Guillermo, Armando, Colomo, Luis, Campo, Elias, Martinez, Antonio
Format: Article
Language:English
Subjects:
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Adult
Aged
Aged, 80 and over
Biopsy
Disease
Epstein-Barr virus
Female
Herpes viruses
Herpesviridae
Herpesviridae Infections - complications
Herpesviridae Infections - pathology
Herpesvirus 8, Human
HIV
Human immunodeficiency virus
Humans
Hyperplasia
Immune system
Infections
Kaposis sarcoma
Laboratory Medicine
Lentivirus
Lymphoma
Lymphoma - pathology
Lymphoma - virology
Lymphoproliferative Disorders - pathology
Lymphoproliferative Disorders - virology
Male
Medicine
Medicine & Public Health
Middle Aged
original-article
Pathology
Retroviridae
Young Adult
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Summary:Human herpesvirus 8 (HHV8)-associated lymphoid proliferations are uncommon and poorly characterized disorders mainly affecting immunosuppressed patients, especially with HIV infection. They encompass different diseases with overlapping features that complicate their classification. In addition, the role of HHV8 in reactive lymphoid hyperplasia is not well known. To analyze the clinicopathological spectrum of these lesions, we have reviewed 66 biopsies of 61 patients with HHV8 infection. All cases were also investigated for Epstein-Barr virus (EBV) and HIV infection. We identified 13 (20%) cases of HHV8-related reactive lymphoid hyperplasia, 2 (3%) HHV8 plasmablastic proliferations of the splenic red pulp, 28 (42%) multicentric Castleman disease, 6 (9%) germinotropic lymphoproliferative disorders, and 17 (26%) HHV8-related lymphomas. As expected, the pathologic subtype was predictive of overall survival (P
ISSN:0893-3952
1530-0285
DOI:10.1038/modpathol.2016.233