Evaluation of kisspeptin levels in obese pregnancy as a biomarker for pre-eclampsia

Summary Objectives  Circulating concentrations of the peptide kisspeptin have been proposed as a novel biomarker for early detection of pre‐eclampsia. Our aims were to assess analytical and clinical performance characteristics of a commercial kisspeptin assay and to determine sensitivity and specifi...

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Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2012-06, Vol.76 (6), p.887-893
Main Authors: Logie, James J., Denison, Fiona C., Riley, Simon C., Ramaesh, Thayalini, Forbes, Shareen, Norman, Jane E., Reynolds, Rebecca M.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Endocrinopathies
Enzyme-Linked Immunosorbent Assay
Female
Fundamental and applied biological sciences. Psychology
Humans
Kisspeptins - blood
Medical sciences
Metabolic diseases
Obesity
Obesity - blood
Obesity - complications
Pre-Eclampsia - blood
Pregnancy
Prospective Studies
Risk Factors
Vertebrates: endocrinology
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Summary:Summary Objectives  Circulating concentrations of the peptide kisspeptin have been proposed as a novel biomarker for early detection of pre‐eclampsia. Our aims were to assess analytical and clinical performance characteristics of a commercial kisspeptin assay and to determine sensitivity and specificity of the test for pre‐eclampsia. Design  Prospective, longitudinal study in a United Kingdom tertiary referral Antenatal Metabolic Clinic. Patients  Severely obese (body mass index, BMI > 40kg/m2, n = 194) and lean (BMI 
ISSN:0300-0664
1365-2265
DOI:10.1111/j.1365-2265.2011.04317.x