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Evaluation of kisspeptin levels in obese pregnancy as a biomarker for pre-eclampsia
Summary Objectives Circulating concentrations of the peptide kisspeptin have been proposed as a novel biomarker for early detection of pre‐eclampsia. Our aims were to assess analytical and clinical performance characteristics of a commercial kisspeptin assay and to determine sensitivity and specifi...
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| Published in: | Clinical endocrinology (Oxford) 2012-06, Vol.76 (6), p.887-893 |
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| container_title | Clinical endocrinology (Oxford) |
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| creator | Logie, James J. Denison, Fiona C. Riley, Simon C. Ramaesh, Thayalini Forbes, Shareen Norman, Jane E. Reynolds, Rebecca M. |
| description | Summary
Objectives Circulating concentrations of the peptide kisspeptin have been proposed as a novel biomarker for early detection of pre‐eclampsia. Our aims were to assess analytical and clinical performance characteristics of a commercial kisspeptin assay and to determine sensitivity and specificity of the test for pre‐eclampsia.
Design Prospective, longitudinal study in a United Kingdom tertiary referral Antenatal Metabolic Clinic.
Patients Severely obese (body mass index, BMI > 40kg/m2, n = 194) and lean (BMI |
| doi_str_mv | 10.1111/j.1365-2265.2011.04317.x |
| format | article |
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Objectives Circulating concentrations of the peptide kisspeptin have been proposed as a novel biomarker for early detection of pre‐eclampsia. Our aims were to assess analytical and clinical performance characteristics of a commercial kisspeptin assay and to determine sensitivity and specificity of the test for pre‐eclampsia.
Design Prospective, longitudinal study in a United Kingdom tertiary referral Antenatal Metabolic Clinic.
Patients Severely obese (body mass index, BMI > 40kg/m2, n = 194) and lean (BMI < 25kg/m2, n = 78) pregnant women.
Measurements A commercial kisspeptin ELISA (Phoenix Pharmaceuticals) was assessed for analytical sensitivity, specificity, precision, linearity, recovery and stability in maternal plasma samples at 16, 28 and 36 weeks gestation. Pre‐eclampsia, defined using International Society for the Study of Hypertension in Pregnancy guidelines; blood pressure; delivery gestation; birthweight.
Results Kisspeptin concentrations were lower in early pregnancy in obese women (P < 0·001), and in women who later developed pre‐eclampsia (P < 0·05), compared with women with uncomplicated pregnancies. For 16‐week plasma kisspeptin in prediction of pre‐eclampsia, area under the receiver‐operator characteristic curve was 0·80 (P < 0·01), positive and negative likelihood ratios were 3·0 and 0·2, and test sensitivity and specificity were 85·7 and 71·4%, respectively. In regression analyses, kisspeptin (16 weeks) associated positively with delivery gestation (P < 0·05) and birthweight (P < 0·0001), and negatively with 28‐ and 36‐week blood pressure (P < 0·0001).
Conclusions Kisspeptin concentration in early pregnancy is a promising biomarker for pre‐eclampsia and low birthweight but cannot be recommended, in isolation, for universal screening because of inadequate test sensitivity and specificity. Large‐scale studies are required to assess its potential in a panel of biomarkers.]]></description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/j.1365-2265.2011.04317.x</identifier><identifier>PMID: 22168508</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Biological and medical sciences ; Endocrinopathies ; Enzyme-Linked Immunosorbent Assay ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Kisspeptins - blood ; Medical sciences ; Metabolic diseases ; Obesity ; Obesity - blood ; Obesity - complications ; Pre-Eclampsia - blood ; Pregnancy ; Prospective Studies ; Risk Factors ; Vertebrates: endocrinology</subject><ispartof>Clinical endocrinology (Oxford), 2012-06, Vol.76 (6), p.887-893</ispartof><rights>2011 Blackwell Publishing Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2011 Blackwell Publishing Ltd.</rights><rights>Copyright © 2012 Blackwell Publishing Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5647-ce04907d279411518b7fe08d9538f9e825766952f5b2476cf6ae9c1e72899c013</citedby><cites>FETCH-LOGICAL-c5647-ce04907d279411518b7fe08d9538f9e825766952f5b2476cf6ae9c1e72899c013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25867706$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22168508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Logie, James J.</creatorcontrib><creatorcontrib>Denison, Fiona C.</creatorcontrib><creatorcontrib>Riley, Simon C.</creatorcontrib><creatorcontrib>Ramaesh, Thayalini</creatorcontrib><creatorcontrib>Forbes, Shareen</creatorcontrib><creatorcontrib>Norman, Jane E.</creatorcontrib><creatorcontrib>Reynolds, Rebecca M.</creatorcontrib><title>Evaluation of kisspeptin levels in obese pregnancy as a biomarker for pre-eclampsia</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description><![CDATA[Summary
Objectives Circulating concentrations of the peptide kisspeptin have been proposed as a novel biomarker for early detection of pre‐eclampsia. Our aims were to assess analytical and clinical performance characteristics of a commercial kisspeptin assay and to determine sensitivity and specificity of the test for pre‐eclampsia.
Design Prospective, longitudinal study in a United Kingdom tertiary referral Antenatal Metabolic Clinic.
Patients Severely obese (body mass index, BMI > 40kg/m2, n = 194) and lean (BMI < 25kg/m2, n = 78) pregnant women.
Measurements A commercial kisspeptin ELISA (Phoenix Pharmaceuticals) was assessed for analytical sensitivity, specificity, precision, linearity, recovery and stability in maternal plasma samples at 16, 28 and 36 weeks gestation. Pre‐eclampsia, defined using International Society for the Study of Hypertension in Pregnancy guidelines; blood pressure; delivery gestation; birthweight.
Results Kisspeptin concentrations were lower in early pregnancy in obese women (P < 0·001), and in women who later developed pre‐eclampsia (P < 0·05), compared with women with uncomplicated pregnancies. For 16‐week plasma kisspeptin in prediction of pre‐eclampsia, area under the receiver‐operator characteristic curve was 0·80 (P < 0·01), positive and negative likelihood ratios were 3·0 and 0·2, and test sensitivity and specificity were 85·7 and 71·4%, respectively. In regression analyses, kisspeptin (16 weeks) associated positively with delivery gestation (P < 0·05) and birthweight (P < 0·0001), and negatively with 28‐ and 36‐week blood pressure (P < 0·0001).
Conclusions Kisspeptin concentration in early pregnancy is a promising biomarker for pre‐eclampsia and low birthweight but cannot be recommended, in isolation, for universal screening because of inadequate test sensitivity and specificity. Large‐scale studies are required to assess its potential in a panel of biomarkers.]]></description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Endocrinopathies</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Kisspeptins - blood</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - complications</subject><subject>Pre-Eclampsia - blood</subject><subject>Pregnancy</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Vertebrates: endocrinology</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqNkV-LEzEUxYMobl39CjIggi8z3iSTfw8-SKmruFRkFcGXkKZ3JN3pzJh01vbbm7G1gi-al1y4v3Nzcw4hBYWK5vNyU1EuRcmYFBUDSiuoOVXV_h6ZnRv3yQw4QAlS1hfkUUobABAa1ENywRiVWoCekZvFnWtHtwt9V_RNcRtSGnDYha5o8Q7bVOSqX2HCYoj4rXOdPxQuFa5YhX7r4i3Gounj1CzRt247pOAekweNaxM-Od2X5PObxaf52_L6w9W7-evr0gtZq9Ij1AbUmilTUyqoXqkGQa-N4LoxqJlQUhrBGrFitZK-kQ6Np6iYNsYD5ZfkxXHuEPvvI6ad3YbksW1dh_2YLNVGcZVh-DcKYCgHzmVGn_2Fbvoxdvkjlopa6MxpkSl9pHzsU4rY2CGGbMghj7JTRnZjpyjsFIWdMrK_MrL7LH16emBcbXF9Fv4OJQPPT4BL3rVNzK6H9IcTWioF06avjtyP0OLhvxew88VyqrK-POpD2uH-rM-pWpmNE_bL8srefF2auWYf7Xv-E6g-uQo</recordid><startdate>201206</startdate><enddate>201206</enddate><creator>Logie, James J.</creator><creator>Denison, Fiona C.</creator><creator>Riley, Simon C.</creator><creator>Ramaesh, Thayalini</creator><creator>Forbes, Shareen</creator><creator>Norman, Jane E.</creator><creator>Reynolds, Rebecca M.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7TS</scope></search><sort><creationdate>201206</creationdate><title>Evaluation of kisspeptin levels in obese pregnancy as a biomarker for pre-eclampsia</title><author>Logie, James J. ; Denison, Fiona C. ; Riley, Simon C. ; Ramaesh, Thayalini ; Forbes, Shareen ; Norman, Jane E. ; Reynolds, Rebecca M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5647-ce04907d279411518b7fe08d9538f9e825766952f5b2476cf6ae9c1e72899c013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Endocrinopathies</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Kisspeptins - blood</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Obesity - complications</topic><topic>Pre-Eclampsia - blood</topic><topic>Pregnancy</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Logie, James J.</creatorcontrib><creatorcontrib>Denison, Fiona C.</creatorcontrib><creatorcontrib>Riley, Simon C.</creatorcontrib><creatorcontrib>Ramaesh, Thayalini</creatorcontrib><creatorcontrib>Forbes, Shareen</creatorcontrib><creatorcontrib>Norman, Jane E.</creatorcontrib><creatorcontrib>Reynolds, Rebecca M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Physical Education Index</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Logie, James J.</au><au>Denison, Fiona C.</au><au>Riley, Simon C.</au><au>Ramaesh, Thayalini</au><au>Forbes, Shareen</au><au>Norman, Jane E.</au><au>Reynolds, Rebecca M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of kisspeptin levels in obese pregnancy as a biomarker for pre-eclampsia</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2012-06</date><risdate>2012</risdate><volume>76</volume><issue>6</issue><spage>887</spage><epage>893</epage><pages>887-893</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract><![CDATA[Summary
Objectives Circulating concentrations of the peptide kisspeptin have been proposed as a novel biomarker for early detection of pre‐eclampsia. Our aims were to assess analytical and clinical performance characteristics of a commercial kisspeptin assay and to determine sensitivity and specificity of the test for pre‐eclampsia.
Design Prospective, longitudinal study in a United Kingdom tertiary referral Antenatal Metabolic Clinic.
Patients Severely obese (body mass index, BMI > 40kg/m2, n = 194) and lean (BMI < 25kg/m2, n = 78) pregnant women.
Measurements A commercial kisspeptin ELISA (Phoenix Pharmaceuticals) was assessed for analytical sensitivity, specificity, precision, linearity, recovery and stability in maternal plasma samples at 16, 28 and 36 weeks gestation. Pre‐eclampsia, defined using International Society for the Study of Hypertension in Pregnancy guidelines; blood pressure; delivery gestation; birthweight.
Results Kisspeptin concentrations were lower in early pregnancy in obese women (P < 0·001), and in women who later developed pre‐eclampsia (P < 0·05), compared with women with uncomplicated pregnancies. For 16‐week plasma kisspeptin in prediction of pre‐eclampsia, area under the receiver‐operator characteristic curve was 0·80 (P < 0·01), positive and negative likelihood ratios were 3·0 and 0·2, and test sensitivity and specificity were 85·7 and 71·4%, respectively. In regression analyses, kisspeptin (16 weeks) associated positively with delivery gestation (P < 0·05) and birthweight (P < 0·0001), and negatively with 28‐ and 36‐week blood pressure (P < 0·0001).
Conclusions Kisspeptin concentration in early pregnancy is a promising biomarker for pre‐eclampsia and low birthweight but cannot be recommended, in isolation, for universal screening because of inadequate test sensitivity and specificity. Large‐scale studies are required to assess its potential in a panel of biomarkers.]]></abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22168508</pmid><doi>10.1111/j.1365-2265.2011.04317.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Endocrinopathies Enzyme-Linked Immunosorbent Assay Female Fundamental and applied biological sciences. Psychology Humans Kisspeptins - blood Medical sciences Metabolic diseases Obesity Obesity - blood Obesity - complications Pre-Eclampsia - blood Pregnancy Prospective Studies Risk Factors Vertebrates: endocrinology |
| title | Evaluation of kisspeptin levels in obese pregnancy as a biomarker for pre-eclampsia |
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