The clinical impact of Anti-DFS70 antibodies in undifferentiated connective tissue disease: case reports and a review of the literature

Anti-nuclear antibody (ANA) positivity suggests CTD but can also lead to a diagnosis of UCTD when a patient does not fulfill the CTD diagnostic criteria. An anti-dense fine speckled (DFS) immunofluorescence (IIF) pattern can be observed when using an ANA test on HEp-2 cells and is due to the presenc...

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Bibliographic Details
Published in:Immunologic research 2017-02, Vol.65 (1), p.293-295
Main Authors: Infantino, M., Meacci, F., Grossi, V., Manfredi, M., Li Gobbi, F., Sarzi-Puttini, P., Atzeni, F., Benucci, M.
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing - immunology
Adult
Allergology
Antibodies - blood
Antibodies, Antinuclear - blood
Biomedical and Life Sciences
Biomedicine
Cell Line, Tumor
Female
Humans
Immunology
Internal Medicine
Medicine/Public Health
Middle Aged
Therapeutic Aspects in Autoimmunity
Transcription Factors - immunology
Undifferentiated Connective Tissue Diseases - blood
Undifferentiated Connective Tissue Diseases - diagnosis
Undifferentiated Connective Tissue Diseases - immunology
Young Adult
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Summary:Anti-nuclear antibody (ANA) positivity suggests CTD but can also lead to a diagnosis of UCTD when a patient does not fulfill the CTD diagnostic criteria. An anti-dense fine speckled (DFS) immunofluorescence (IIF) pattern can be observed when using an ANA test on HEp-2 cells and is due to the presence of antibodies to the nuclear DFS70 antigen that has rarely found in CTD. Serological testing for anti-DFS70 antibodies could therefore play a very interesting negative predictive role in stratifying patients on the basis of the evolution of UCTD to CTD. We described two patients ANA and anti-DFS70 positive in which the use of new method allowing the immunoadsorption of anti-DFS70 antibodies has permitted to exclude the incorrect diagnosis of CTD.
ISSN:0257-277X
1559-0755
DOI:10.1007/s12026-016-8836-4