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Dental treatments, tooth extractions, and osteonecrosis of the jaw in Japanese patients with rheumatoid arthritis: results from the IORRA cohort study
This study aimed to evaluate dental treatments, tooth extractions, and osteonecrosis of the jaw (ONJ) in Japanese patients with rheumatoid arthritis (RA). Patients with RA enrolled in our cohort completed self-administered questionnaires, which included questions regarding their dental treatments, t...
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Published in: | Journal of bone and mineral metabolism 2017-05, Vol.35 (3), p.344-350 |
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description | This study aimed to evaluate dental treatments, tooth extractions, and osteonecrosis of the jaw (ONJ) in Japanese patients with rheumatoid arthritis (RA). Patients with RA enrolled in our cohort completed self-administered questionnaires, which included questions regarding their dental treatments, tooth extractions by dentists during the past 6 months, and past history of ONJ. The history of ONJ was validated with the patients’ medical records. Logistic regression was used to determine the association of variables with dental treatments and tooth extractions during the past 6 months. Among 5695 Japanese patients with RA who responded to the questionnaires (mean age, 61.0 years; 85.6 % female), 2323 patients (40.8 %) and 378 patients (6.6 %) reported having had dental treatments and tooth extractions performed by a dentist within the past 6 months, respectively. In multivariate models, advanced age was significantly (
P
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doi_str_mv | 10.1007/s00774-016-0763-x |
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P
< 0.0001) associated with both dental treatments and tooth extractions during the prior 6-month period, and ever smoking was significantly (
P
= 0.023) correlated with tooth extractions during that time. Among patients who reported a history of ONJ, we confirmed five cases of ONJ with patient medical records. The prevalence of ONJ was 0.094 % among all RA patients and 0.26 % among female RA patients ≥65 years of age (
n
= 1888). Our data suggest that more than a few Japanese patients with RA have dental complications that require care by dentists, and that Japanese rheumatologists and dentists should cooperate to improve dental health in patients with RA.</description><identifier>ISSN: 0914-8779</identifier><identifier>EISSN: 1435-5604</identifier><identifier>DOI: 10.1007/s00774-016-0763-x</identifier><identifier>PMID: 27372662</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Arthritis, Rheumatoid - complications ; Asian Continental Ancestry Group ; Cohort Studies ; Female ; Humans ; Jaw Diseases - complications ; Jaw Diseases - diagnosis ; Logistic Models ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Multivariate Analysis ; Original Article ; Orthopedics ; Osteonecrosis - complications ; Osteonecrosis - diagnosis ; Surveys and Questionnaires ; Tooth Extraction</subject><ispartof>Journal of bone and mineral metabolism, 2017-05, Vol.35 (3), p.344-350</ispartof><rights>The Japanese Society for Bone and Mineral Research and Springer Japan 2016</rights><rights>Journal of Bone and Mineral Metabolism is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-e7fac4ead7f079b669e821b0193277e7fd2f9cd33f54bbd552d99307be693e233</citedby><cites>FETCH-LOGICAL-c429t-e7fac4ead7f079b669e821b0193277e7fd2f9cd33f54bbd552d99307be693e233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27372662$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Furuya, Takefumi</creatorcontrib><creatorcontrib>Maeda, Shigeru</creatorcontrib><creatorcontrib>Momohara, Shigeki</creatorcontrib><creatorcontrib>Taniguchi, Atsuo</creatorcontrib><creatorcontrib>Yamanaka, Hisashi</creatorcontrib><title>Dental treatments, tooth extractions, and osteonecrosis of the jaw in Japanese patients with rheumatoid arthritis: results from the IORRA cohort study</title><title>Journal of bone and mineral metabolism</title><addtitle>J Bone Miner Metab</addtitle><addtitle>J Bone Miner Metab</addtitle><description>This study aimed to evaluate dental treatments, tooth extractions, and osteonecrosis of the jaw (ONJ) in Japanese patients with rheumatoid arthritis (RA). Patients with RA enrolled in our cohort completed self-administered questionnaires, which included questions regarding their dental treatments, tooth extractions by dentists during the past 6 months, and past history of ONJ. The history of ONJ was validated with the patients’ medical records. Logistic regression was used to determine the association of variables with dental treatments and tooth extractions during the past 6 months. Among 5695 Japanese patients with RA who responded to the questionnaires (mean age, 61.0 years; 85.6 % female), 2323 patients (40.8 %) and 378 patients (6.6 %) reported having had dental treatments and tooth extractions performed by a dentist within the past 6 months, respectively. In multivariate models, advanced age was significantly (
P
< 0.0001) associated with both dental treatments and tooth extractions during the prior 6-month period, and ever smoking was significantly (
P
= 0.023) correlated with tooth extractions during that time. Among patients who reported a history of ONJ, we confirmed five cases of ONJ with patient medical records. The prevalence of ONJ was 0.094 % among all RA patients and 0.26 % among female RA patients ≥65 years of age (
n
= 1888). Our data suggest that more than a few Japanese patients with RA have dental complications that require care by dentists, and that Japanese rheumatologists and dentists should cooperate to improve dental health in patients with RA.</description><subject>Arthritis, Rheumatoid - complications</subject><subject>Asian Continental Ancestry Group</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Jaw Diseases - complications</subject><subject>Jaw Diseases - diagnosis</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Osteonecrosis - complications</subject><subject>Osteonecrosis - diagnosis</subject><subject>Surveys and Questionnaires</subject><subject>Tooth Extraction</subject><issn>0914-8779</issn><issn>1435-5604</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqFkctu1TAQhi0EoofCA7BBltiwINSXxBOzq8qtqFKlCtaWk0yIj5L4YDvq6YvwvHU4pUJIqBvb8nz-rJmfkJecveOMwUnMC5QF46pgoGSxf0Q2vJRVUSlWPiYbpnlZ1AD6iDyLccsYhwr4U3IkQIJQSmzIrw84JzvSFNCmKZ_jW5q8TwPFfQq2Tc7P-crOHfUxoZ-xDT66SH1P04B0a6-pm-lXu7MzRqQ7m9xqodcuO8KAy2STdx21IQ3BJRff04BxGTPSBz_9lpxfXl2d0tYPPiQa09LdPCdPejtGfHG3H5Pvnz5-O_tSXFx-Pj87vSjaUuhUIPS2LdF20DPQjVIaa8EbxrUUALnaiV63nZR9VTZNV1Wi01oyaFBpiULKY_Lm4N0F_3PBmMzkYovjmLvxSzS81iBrxvNUH0aFAl4yqTP6-h9065cw50ZWodCshnql-IFaJxoD9mYX3GTDjeHMrPmaQ74m52vWfM0-v3l1Z16aCbv7F38CzYA4ADGX5h8Y_vr6v9ZbcOKzAQ</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Furuya, Takefumi</creator><creator>Maeda, Shigeru</creator><creator>Momohara, Shigeki</creator><creator>Taniguchi, Atsuo</creator><creator>Yamanaka, Hisashi</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20170501</creationdate><title>Dental treatments, tooth extractions, and osteonecrosis of the jaw in Japanese patients with rheumatoid arthritis: results from the IORRA cohort study</title><author>Furuya, Takefumi ; Maeda, Shigeru ; Momohara, Shigeki ; Taniguchi, Atsuo ; Yamanaka, Hisashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-e7fac4ead7f079b669e821b0193277e7fd2f9cd33f54bbd552d99307be693e233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Arthritis, Rheumatoid - complications</topic><topic>Asian Continental Ancestry Group</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Jaw Diseases - complications</topic><topic>Jaw Diseases - diagnosis</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Osteonecrosis - complications</topic><topic>Osteonecrosis - diagnosis</topic><topic>Surveys and Questionnaires</topic><topic>Tooth Extraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Furuya, Takefumi</creatorcontrib><creatorcontrib>Maeda, Shigeru</creatorcontrib><creatorcontrib>Momohara, Shigeki</creatorcontrib><creatorcontrib>Taniguchi, Atsuo</creatorcontrib><creatorcontrib>Yamanaka, Hisashi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of bone and mineral metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Furuya, Takefumi</au><au>Maeda, Shigeru</au><au>Momohara, Shigeki</au><au>Taniguchi, Atsuo</au><au>Yamanaka, Hisashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dental treatments, tooth extractions, and osteonecrosis of the jaw in Japanese patients with rheumatoid arthritis: results from the IORRA cohort study</atitle><jtitle>Journal of bone and mineral metabolism</jtitle><stitle>J Bone Miner Metab</stitle><addtitle>J Bone Miner Metab</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>35</volume><issue>3</issue><spage>344</spage><epage>350</epage><pages>344-350</pages><issn>0914-8779</issn><eissn>1435-5604</eissn><abstract>This study aimed to evaluate dental treatments, tooth extractions, and osteonecrosis of the jaw (ONJ) in Japanese patients with rheumatoid arthritis (RA). Patients with RA enrolled in our cohort completed self-administered questionnaires, which included questions regarding their dental treatments, tooth extractions by dentists during the past 6 months, and past history of ONJ. The history of ONJ was validated with the patients’ medical records. Logistic regression was used to determine the association of variables with dental treatments and tooth extractions during the past 6 months. Among 5695 Japanese patients with RA who responded to the questionnaires (mean age, 61.0 years; 85.6 % female), 2323 patients (40.8 %) and 378 patients (6.6 %) reported having had dental treatments and tooth extractions performed by a dentist within the past 6 months, respectively. In multivariate models, advanced age was significantly (
P
< 0.0001) associated with both dental treatments and tooth extractions during the prior 6-month period, and ever smoking was significantly (
P
= 0.023) correlated with tooth extractions during that time. Among patients who reported a history of ONJ, we confirmed five cases of ONJ with patient medical records. The prevalence of ONJ was 0.094 % among all RA patients and 0.26 % among female RA patients ≥65 years of age (
n
= 1888). Our data suggest that more than a few Japanese patients with RA have dental complications that require care by dentists, and that Japanese rheumatologists and dentists should cooperate to improve dental health in patients with RA.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>27372662</pmid><doi>10.1007/s00774-016-0763-x</doi><tpages>7</tpages></addata></record> |
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subjects | Arthritis, Rheumatoid - complications Asian Continental Ancestry Group Cohort Studies Female Humans Jaw Diseases - complications Jaw Diseases - diagnosis Logistic Models Male Medicine Medicine & Public Health Metabolic Diseases Middle Aged Multivariate Analysis Original Article Orthopedics Osteonecrosis - complications Osteonecrosis - diagnosis Surveys and Questionnaires Tooth Extraction |
title | Dental treatments, tooth extractions, and osteonecrosis of the jaw in Japanese patients with rheumatoid arthritis: results from the IORRA cohort study |
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