Are the autoimmune/inflammatory syndrome induced by adjuvants (ASIA) and the undifferentiated connective tissue disease (UCTD) related to each other? A case-control study of environmental exposures

The autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is an entity that includes different autoimmune conditions observed after exposure to an adjuvant. Patients with undifferentiated connective tissue disease (UCTD) present many signs and symptoms of ASIA, alluding to the idea that an ex...

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Bibliographic Details
Published in:Immunologic research 2017-02, Vol.65 (1), p.150-156
Main Authors: Scanzi, F., Andreoli, L., Martinelli, M., Taraborelli, M., Cavazzana, I., Carabellese, N., Ottaviani, R., Allegri, F., Franceschini, F., Agmon-Levin, N., Shoenfeld, Y., Tincani, Angela
Format: Article
Language:English
Subjects:
Adjuvants
Adjuvants, Immunologic - adverse effects
Adjuvants, Pharmaceutic - adverse effects
Adult
Aged
Allergology
Antigens
Autoantibodies
Autoimmune diseases
Autoimmunity
Biomedical and Life Sciences
Biomedicine
Cardiolipin
Case-Control Studies
Cigarette smoking
Connective tissue diseases
Connective tissues
Deoxyribonucleic acid
DNA
Environment and Autoimmunity
Environmental Exposure - adverse effects
Exposure
Extractive metallurgy
Family medical history
Fatigue
Female
Foundries
Genetics
Glycoprotein I
Glycoproteins
Hepatitis B virus
Humans
Immunology
Implants
Inflammation
Internal Medicine
Irritable bowel syndrome
Italy - epidemiology
Male
Malignancy
Medicine/Public Health
Middle Aged
Occupational exposure
Occupational health
Papillomavirus Vaccines - adverse effects
Patients
Phenotypes
Prostheses and Implants - adverse effects
Signs and symptoms
Silicones
Silicones - adverse effects
Smoking - adverse effects
Syndrome
Tetanus
Tetanus Toxoid - adverse effects
Undifferentiated Connective Tissue Diseases - etiology
Vaccination - adverse effects
Vaccines
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Description
Summary:The autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is an entity that includes different autoimmune conditions observed after exposure to an adjuvant. Patients with undifferentiated connective tissue disease (UCTD) present many signs and symptoms of ASIA, alluding to the idea that an exposure to adjuvants can be a trigger also for UCTD. The aim of this case-control study was to investigate exposure to adjuvants prior to disease onset in patients affected by UCTD. Ninety-two UCTD patients and 92 age- and sex-matched controls with no malignancy, chronic infections, autoimmune disease nor family history of autoimmune diseases were investigated for exposure to adjuvants. An ad hoc-created questionnaire exploring the exposure to vaccinations, foreign materials and environmental and occupational exposures was administered to both cases and controls. Autoantibodies were also analyzed (anti-nuclear, anti-extractable nuclear antigens, anti-double-stranded DNA, anti-cardiolipin, anti-β2 glycoprotein I). UCTD patients displayed a greater exposure to HBV ( p  = 0.018) and tetanus toxoid ( p  
ISSN:0257-277X
1559-0755
DOI:10.1007/s12026-017-8912-4