Evidence for direct effects of glyphosate on ovarian function: glyphosate influences steroidogenesis and proliferation of bovine granulosa but not theca cells in vitro

Glyphosate (GLY) is a common herbicide used worldwide but its effect on ovarian function in mammals is unknown. The aim of this study was to determine the potential endocrine disruptor effects of GLY on ovarian function evaluating cell proliferation, steroidogenesis and gene expression using bovine...

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Bibliographic Details
Published in:Journal of applied toxicology 2017-06, Vol.37 (6), p.692-698
Main Authors: Perego, Maria Chiara, Schutz, Luis F., Caloni, Francesca, Cortinovis, Cristina, Albonico, Marco, Spicer, Leon J.
Format: Article
Language:English
Subjects:
Animals
Bovine
Cattle
Cell Culture Techniques
Cell growth
Cell proliferation
Cell Proliferation - drug effects
Cells, Cultured
Dose-Response Relationship, Drug
Endocrine Disruptors - toxicity
Estradiol - biosynthesis
Female
Gene expression
Glycine - analogs & derivatives
Glycine - toxicity
Glyphosate
Gonadal Steroid Hormones - biosynthesis
Granulosa cell
Granulosa Cells - drug effects
Granulosa Cells - metabolism
Granulosa Cells - pathology
Hormone replacement therapy
Progesterone - biosynthesis
Reproductive system
Steroidogenesis
Theca cell
Theca Cells - drug effects
Theca Cells - metabolism
Theca Cells - pathology
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Summary:Glyphosate (GLY) is a common herbicide used worldwide but its effect on ovarian function in mammals is unknown. The aim of this study was to determine the potential endocrine disruptor effects of GLY on ovarian function evaluating cell proliferation, steroidogenesis and gene expression using bovine granulosa cells (GC) and theca cells as in vitro models. GC proliferation was impaired (P 
ISSN:0260-437X
1099-1263
DOI:10.1002/jat.3417