Cytophysiological Changes in the Follicular Epithelium of the Thyroid Gland after Long-Term Exposure to Low Doses of Dichlorodiphenyltrichloroethane (DDT)

Exposure to endocrine disruptors is considered as a risk factor thyroid gland diseases. We analyzed cytophysiological changes in rat thyroid follicular epithelium after long-term exposure to low doses of the most widespread disruptor DDT. Analysis of thyroid hormone production and light and electron...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2017-03, Vol.162 (5), p.699-702
Main Authors: Yaglova, N. V., Yaglov, V. V.
Format: Article
Language:English
Subjects:
Analysis
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
DDT
DDT - toxicity
Electron microscopy
Endocrine disruptors
Epithelium
Epithelium - drug effects
Epithelium - pathology
Golgi apparatus
Health risk assessment
Internal Medicine
Laboratory Medicine
Male
Pathology
Pesticides
Pesticides - toxicity
Rats, Wistar
Thyroid
Thyroid diseases
Thyroid gland
Thyroid Gland - drug effects
Thyroid Gland - pathology
Thyroid hormones
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Summary:Exposure to endocrine disruptors is considered as a risk factor thyroid gland diseases. We analyzed cytophysiological changes in rat thyroid follicular epithelium after long-term exposure to low doses of the most widespread disruptor DDT. Analysis of thyroid hormone production and light and electron microscopy of thyroid gland samples revealed cytophysiological changes in thyroid epithelium related to impaired transport through the apical membrane, suppressed Golgi complex activity, and impaired thyrotrophic hormone regulation of the secretory functions of thyroid cells, which led to compensatory transition from merocrine to microapocrine secret release.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-017-3691-4