Albumin in the Vitreous Body, Retina and Lens of Human Fetal Eye

The content of serum albumin was evaluated in the vitreous body, retina, and lens of human fetuses of 14, 16, 17, 18 and 24 weeks of gestation. Albumin was detected in these tissues. PCR analysis revealed no albumin mRNA in the retina or in the lens, while in fetal liver (control) mRNA for this prot...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2017-03, Vol.162 (5), p.629-631
Main Authors: Panova, I. G., Tatikolov, A. S., Smirnova, Yu. A., Poltavtseva, R. A., Sukhikh, G. T.
Format: Article
Language:English
Subjects:
Albumin
Antioxidants (Nutrients)
Biomedical and Life Sciences
Biomedicine
Cell Biology
Eye lens
Fetus - metabolism
Fetuses
Gene Expression
Gestation
Humans
Internal Medicine
Laboratory Medicine
Liver
Liver - metabolism
mRNA
Pathology
Polymerase chain reaction
Pregnancy
Retina
Retina - metabolism
RNA
Serum Albumin - genetics
Serum Albumin - metabolism
Vitreous Body - metabolism
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Summary:The content of serum albumin was evaluated in the vitreous body, retina, and lens of human fetuses of 14, 16, 17, 18 and 24 weeks of gestation. Albumin was detected in these tissues. PCR analysis revealed no albumin mRNA in the retina or in the lens, while in fetal liver (control) mRNA for this protein was expressed. These findings suggest that serum albumin is not synthesized by cells of retina and lens, but is captured by them. The presence of serum albumin in human eye tissues suggests its involvement in the metabolism, maintenance of tissue volume, and antioxidant reactions.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-017-3673-6