Maternal thyroid parameters, body mass index and subsequent weight gain during pregnancy in healthy euthyroid women

Summary Context Obesity and too much weight gain during gestation have a negative effect on obstetric and neonatal outcomes. Objective To determine the relationship between thyroid hormone parameters, body mass index (BMI) and weight gain during gestation. Design Prospective follow‐up study of thyro...

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Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2013-10, Vol.79 (4), p.577-583
Main Authors: Pop, Victor J., Biondi, Bernadette, Wijnen, Hennie A., Kuppens, Simone M., LVader, Huib
Format: Article
Language:English
Subjects:
Adult
Age Factors
Autoantibodies - blood
Biological and medical sciences
Body Mass Index
Endocrinopathies
European Continental Ancestry Group
Female
Fundamental and applied biological sciences. Psychology
Hormones
Humans
Iodide Peroxidase - immunology
Logistic Models
Medical sciences
Medical treatment
Netherlands
Obesity - blood
Obesity - ethnology
Obesity - physiopathology
Parity
Pregnancy
Pregnancy Complications - blood
Pregnancy Complications - ethnology
Pregnancy Complications - physiopathology
Pregnancy Trimester, First
Pregnancy Trimesters
Prospective Studies
Thyroid Gland - metabolism
Thyroid Gland - physiology
Thyrotropin - blood
Thyroxine - blood
Vertebrates: endocrinology
Weight Gain - ethnology
Weight Gain - physiology
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Summary:Summary Context Obesity and too much weight gain during gestation have a negative effect on obstetric and neonatal outcomes. Objective To determine the relationship between thyroid hormone parameters, body mass index (BMI) and weight gain during gestation. Design Prospective follow‐up study of thyroid parameters and gestational weight gain. Setting Healthy pregnant women, included at first antenatal consultation. Patients Thyroid function (TSH, FT4 and TPO‐Ab) was assessed at 12, 24 and 36 weeks’ gestation in 1035 Dutch Caucasian women who delivered at ≥37 weeks. BMI (WHO criteria) was assessed at eight weeks, and weight gain throughout gestation was also assessed using the US Institute of Medicine (IOM) criteria. Measurements Primary outcome measure: a possible relationship between maternal thyroid parameters and BMI at the first trimester. Secondary outcome measure: the relationship between thyroid parameters and weight gain throughout gestation. Results At 12 weeks’ gestation, BMI correlated with FT4 (r = −0·14, P 
ISSN:0300-0664
1365-2265
DOI:10.1111/cen.12177