Impaired exercise capacity after lung transplantation is related to delayed recovery of muscle strength

Lung transplant recipients report reduced exercise capacity despite satisfactory graft function. We analysed changes in lung function, six‐min walk distance (6MWD), and quadriceps strength in the first 26‐wk post‐transplant and examined what factors predict 6MWD recovery. All lung transplant recipie...

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Bibliographic Details
Published in:Clinical transplantation 2013-07, Vol.27 (4), p.E504-E511
Main Authors: Walsh, James R., Chambers, Daniel C., Davis, Rebecca J., Morris, Norman R., Seale, Helen E., Yerkovich, Stephanie T., Hopkins, Peter M.A.
Format: Article
Language:English
Subjects:
Adult
Exercise Tolerance
Female
Follow-Up Studies
Humans
Lung Diseases - surgery
lung transplant
Lung Transplantation - rehabilitation
Male
Middle Aged
muscle strength
Muscle Strength - physiology
Prognosis
Prospective Studies
pulmonary rehabilitation
Quality of Life
Recovery of Function - physiology
Respiratory Function Tests
six-min walk test
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Summary:Lung transplant recipients report reduced exercise capacity despite satisfactory graft function. We analysed changes in lung function, six‐min walk distance (6MWD), and quadriceps strength in the first 26‐wk post‐transplant and examined what factors predict 6MWD recovery. All lung transplant recipients at a single institution between June 2007 and January 2011 were considered for inclusion. Lung function, 6MWD, and quadriceps strength corrected for body weight (QS%) were recorded pre‐ and two‐, six‐, 13‐, and 26‐wk post‐transplant. Fifty recipients, of mean (±SD) age 42 (±13) yr, were studied. Mean FEV1% and 6MWD improved from 26.4% to 88.9% and from 397 to 549 m at 26 wk, respectively (both p 
ISSN:0902-0063
1399-0012
DOI:10.1111/ctr.12163