Nickel-Catalyzed Reductive Dicarbofunctionalization of Alkenes

An intermolecular, three-component reductive dicarbofunctionalization of alkenes is presented here. The combination of Ni catalysis with TDAE as final reductant enables the direct formation of Csp3–Csp3 and Csp3–Csp2 bonds across a variety of π-systems using two different electrophiles that are sequ...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2017-05, Vol.139 (20), p.6835-6838
Main Authors: García-Domínguez, Andrés, Li, Zhaodong, Nevado, Cristina
Format: Article
Language:English
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Summary:An intermolecular, three-component reductive dicarbofunctionalization of alkenes is presented here. The combination of Ni catalysis with TDAE as final reductant enables the direct formation of Csp3–Csp3 and Csp3–Csp2 bonds across a variety of π-systems using two different electrophiles that are sequentially activated with exquisite selectivity under mild reaction conditions.
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.7b03195