Prenatal Nonylphenol and Bisphenol A Exposures and Inflammation Are Determinants of Oxidative/Nitrative Stress: A Taiwanese Cohort Study

• Published in: Environmental science & technology 2017-06, Vol.51 (11), p.6422-6429
• Main Authors: Huang, Yu-Fang, Wang, Pei-Wei, Huang, Li-Wei, Lai, Chun-Hao, Yang, Winnie, Wu, Kuen-Yuh, Lu, Chensheng Alex, Chen, Hsin-Chang, Chen, Mei-Lien
• Format: Article
• Language: English
• Subjects: 8-Hydroxydeoxyguanosine; Adult; Antioxidants; Benzhydryl Compounds - toxicity; Binding sites; Biomarkers; Bisphenol A; C-reactive protein; Cohort analysis; Cohort Studies; Cord blood; Cytokines; Damage; Deoxyguanosine; Deoxyribonucleic acid; Disruption; DNA; DNA Damage; Endocrine disruptors; Estrogens; Exposure; Female; Fetal Blood; Fetuses; Glutathione; Glutathione peroxidase; Human exposure; Humans; Inflammation; Interleukin 6; Interleukins; Lipid peroxidation; Maternal Exposure; Nonylphenol; Oxidative Stress; Peroxidase; Peroxidation; Phenols - toxicity; Pregnancy; Prenatal development; Prenatal experience; Prenatal exposure; Prostaglandins; Tumor Necrosis Factor-alpha - blood; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Umbilical cord
• ISSN: 0013-936X; 1520-5851
• DOI: 10.1021/acs.est.7b00801

Prenatal exposure to nonylphenol (NP) and/or bisphenol A (BPA) has been reported to be associated with adverse birth outcomes; however, the underlying mechanisms remain unclear. The primary mechanism is endocrine disruption of the binding affinity for the estrogen receptor, but oxidative stress and inflammation might also play a contributory role. We aimed to investigate urinary NP and BPA levels in relation to biomarkers of oxidative/nitrative stress and inflammation and to explore whether changes in oxidative/nitrative stress are a function of prenatal exposure to NP/BPA and inflammation in 241 mother-fetus pairs. Third-trimester urinary biomarkers of oxidative/nitrative stress were simultaneously measured, including products of oxidatively and nitratively damaged DNA (8-hydroxy-2′-deoxyguanosine (8-OHdG) and 8-nitroguanine (8-NO2Gua)) as well as products of lipid peroxidation (8-iso-prostaglandin F2α (8-isoPF2α) and 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA)). The antioxidant glutathione peroxidase (GPx) and inflammation biomarkers, including C-reactive protein (CRP) and a panel of cytokines (interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α)), were analyzed in maternal and umbilical cord plasma samples. In adjusted models, we observed significant positive associations between NP exposure and 8-OHdG and 8-NO2Gua levels, between BPA and 8-isoPF2α levels, and between maternal CRP levels and HNE-MA levels. Additionally, BPA and TNF-α levels in cord blood were inversely associated with maternal and GPx levels in cord blood as well as maternal TNF-α levels were inversely associated with maternal GPx levels. These results support a role for exposure to NP and BPA and possibly inflammation in increasing oxidative/nitrative stress and decreasing antioxidant activity during pregnancy.