Synthesis of 4‑Halo-3(2H)‑furanones Using Intramolecular Cyclization of Sulfonium Salts

A simple and efficient synthesis of 4-halo-3­(2H)-furanones by halogenative intramolecular cyclization of sulfonium salts is described, which can expedite the production of a variety of 4-bromo- or 4-iodo-3­(2H)-furanones, useful synthetic building blocks, in good to high yield under mild conditions...

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Bibliographic Details
Published in:Journal of organic chemistry 2017-06, Vol.82 (11), p.5583-5589
Main Authors: Inagaki, Sho, Nakazato, Maiko, Fukuda, Nozomi, Tamura, Satoru, Kawano, Tomikazu
Format: Article
Language:English
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Summary:A simple and efficient synthesis of 4-halo-3­(2H)-furanones by halogenative intramolecular cyclization of sulfonium salts is described, which can expedite the production of a variety of 4-bromo- or 4-iodo-3­(2H)-furanones, useful synthetic building blocks, in good to high yield under mild conditions.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.7b00399