Mucoepidermoid Carcinoma Post-Radioactive Iodine Treatment for Papillary Thyroid Carcinoma: Unique presentation and putative etiologic association

We report the development of mucoepidermoid carcinomas (MEC) of the parotid gland in two adult patients after a relatively short duration of radioactive iodine (RAI) treatment for papillary thyroid carcinoma (PTC). Both instances, together with those previously reported, underscore the selective nat...

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Bibliographic Details
Published in:Human pathology 2017-10, Vol.68, p.189-192
Main Authors: Saluja, Karan, MD, Butler, Randall T, MD, Pytynia, Kristen B., MD, Zhao, Bihong, MD, PhD, Karni, Ron J., MD, Weber, Randal S., MD, El-Naggar, Adel K., MD, PhD
Format: Article
Language:English
Subjects:
Age
Aged
Biopsy
Cancer therapies
Carcinoma, Mucoepidermoid - etiology
Carcinoma, Mucoepidermoid - genetics
Carcinoma, Mucoepidermoid - pathology
Carcinoma, Mucoepidermoid - surgery
Carcinoma, Papillary - pathology
Carcinoma, Papillary - radiotherapy
Chromosomes
Chromosomes, Human - genetics
Cytogenetic Analysis
Female
Humans
Iodine
Iodine Radioisotopes - adverse effects
Lymphatic system
Male
Medical imaging
Metastasis
Middle Aged
Mucoepidermoid carcinoma
Neoplasms, Radiation-Induced - etiology
Neoplasms, Radiation-Induced - pathology
Neoplasms, Radiation-Induced - surgery
Oral cancer
Papillary thyroid carcinoma
Parotid Neoplasms - etiology
Parotid Neoplasms - genetics
Parotid Neoplasms - pathology
Parotid Neoplasms - surgery
Pathology
Patients
Radioactive iodine treatment
Radiopharmaceuticals - adverse effects
Risk Factors
Salivary gland carcinoma
Secondary carcinoma
Thyroid cancer
Thyroid Cancer, Papillary
Thyroid Neoplasms - pathology
Thyroid Neoplasms - radiotherapy
Tumors
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Description
Summary:We report the development of mucoepidermoid carcinomas (MEC) of the parotid gland in two adult patients after a relatively short duration of radioactive iodine (RAI) treatment for papillary thyroid carcinoma (PTC). Both instances, together with those previously reported, underscore the selective nature of the MEC phenotype development in patients with PTC as a consequence of RAI treatment. Efforts to alleviate salivary pathophysiologic damage by RAI in these patients are warranted.
ISSN:0046-8177
1532-8392
DOI:10.1016/j.humpath.2017.04.019