Association Between Brain-Derived Neurotrophic Factor Genotype and Upper Extremity Motor Outcome After Stroke

• Published in: Stroke (1970) 2017-06, Vol.48 (6), p.1457-1462
• Main Authors: Chang, Won Hyuk, Park, Eunhee, Lee, Jungsoo, Lee, Ahee, Kim, Yun-Hee
• Format: Article
• Language: English
• Subjects: Adult; Aged; Brain-Derived Neurotrophic Factor - genetics; Female; Follow-Up Studies; Genotype; Humans; Male; Middle Aged; Movement Disorders - etiology; Movement Disorders - physiopathology; Outcome Assessment (Health Care); Prognosis; Pyramidal Tracts - physiopathology; Severity of Illness Index; Stroke - complications; Stroke - physiopathology; Upper Extremity - physiopathology
• ISSN: 0039-2499; 1524-4628
• DOI: 10.1161/STROKEAHA.116.015264

BACKGROUND AND PURPOSE—The identification of intrinsic factors for predicting upper extremity motor outcome could aid the design of individualized treatment plans in stroke rehabilitation. The aim of this study was to identify prognostic factors, including intrinsic genetic factors, for upper extremity motor outcome in patients with subacute stroke. METHODS—A total of 97 patients with subacute stroke were enrolled. Upper limb motor impairment was scored according to the upper limb of Fugl-Meyer assessment score at 3 months after stroke. The prediction of upper extremity motor outcome at 3 months was modeled using various factors that could potentially influence this impairment, including patient characteristics, baseline upper extremity motor impairment, functional and structural integrity of the corticospinal tract, and brain-derived neurotrophic factor genotype. Multivariate ordinal logistic regression models were used to identify the significance of each factor. RESULTS—The independent predictors of motor outcome at 3 months were baseline upper extremity motor impairment, age, stroke type, and corticospinal tract functional integrity in all stroke patients. However, in the group with severe motor impairment at baseline (upper limb score of Fugl-Meyer assessment