PROXiMATE: a database of mutant protein-protein complex thermodynamics and kinetics

We have developed PROXiMATE, a database of thermodynamic data for more than 6000 missense mutations in 174 heterodimeric protein-protein complexes, supplemented with interaction network data from STRING database, solvent accessibility, sequence, structural and functional information, experimental co...

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Bibliographic Details
Published in:Bioinformatics (Oxford, England) England), 2017-09, Vol.33 (17), p.2787-2788
Main Authors: Jemimah, Sherlyn, Yugandhar, K, Michael Gromiha, M
Format: Article
Language:English
Subjects:
Databases, Factual
Kinetics
Mutant Proteins - chemistry
Mutant Proteins - genetics
Mutant Proteins - metabolism
Mutation, Missense
Protein Interaction Domains and Motifs
Protein Multimerization
Thermodynamics
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Summary:We have developed PROXiMATE, a database of thermodynamic data for more than 6000 missense mutations in 174 heterodimeric protein-protein complexes, supplemented with interaction network data from STRING database, solvent accessibility, sequence, structural and functional information, experimental conditions and literature information. Additional features include complex structure visualization, search and display options, download options and a provision for users to upload their data. The database is freely available at http://www.iitm.ac.in/bioinfo/PROXiMATE/ . The website is implemented in Python, and supports recent versions of major browsers such as IE10, Firefox, Chrome and Opera. gromiha@iitm.ac.in. Supplementary data are available at Bioinformatics online.
ISSN:1367-4803
1367-4811
DOI:10.1093/bioinformatics/btx312