Comparison of pharyngocutaneous fistula closure with and without bacterial cellulose in a rat model

• Published in: Auris, nasus, larynx nasus, larynx, 2018-04, Vol.45 (2), p.301-305
• Main Authors: Demir, Berat, Sarı, Murat, Binnetoglu, Adem, Yumusakhuylu, Ali Cemal, Filinte, Deniz, Tekin, İshak Özel, Bağlam, Tekin, Batman, Abdullah Çağlar
• Format: Article
• Language: English
• Subjects: Bacterial cellulose; Complications of total laryngectomy; Otolaryngology; Pharyngocutaneous fıstula
• ISSN: 0385-8146; 1879-1476
• DOI: 10.1016/j.anl.2017.04.005

Abstract Objective The present study aimed to compare the effects of bacterial cellulose used for closure of pharyngocutaneous fistulae, a complication of total laryngectomy, with those of primary sutures in a rat model. Methods Thirty female Sprague-Dawley underwent experimental pharyngoesophagotomy and were grouped depending on the material used for pharyngocutaneous fistula closure: group I, which received primary sutures alone, group II, which received bacterial cellulose alone; and group III, which received both. After 7 days, the rats were sacrificed. Pharyngocutaneous fistula development was assessed, the gross wound was inspected, and histological examination was conducted. Results Pharyngocutaneous fistulae developed in 12 rats (41%) in all: 6 from group I (21%), 4 from group II (14%) and 2 from group III (7%). Conclusion Fibroblast density and inflammatory cell infiltration were significantly greater in group III than group I. We concluded that bacterial cellulose may be useful for pharyngocutaneous fistula closure.