Pathogenesis and FDG-PET/CT findings of Epstein–Barr virus-related lymphoid neoplasms

Epstein–Barr virus (EBV) is one of the most common viruses, infecting more than 90% of the adult population worldwide. EBV genome is detected in some lymphoid neoplasms. Not only their histopathological subtypes, but also their backgrounds and their clinical courses are variable. A number of B-cell...

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Bibliographic Details
Published in:Annals of nuclear medicine 2017-07, Vol.31 (6), p.425-436
Main Authors: Toriihara, Akira, Nakajima, Reiko, Arai, Ayako, Nakadate, Masashi, Abe, Koichiro, Kubota, Kazunori, Tateishi, Ukihide
Format: Article
Language:English
Subjects:
Computed tomography
Diseases
Disorders
Emission analysis
Epstein-Barr virus
Genomes
Glucose
Herpesvirus 4, Human - physiology
Humans
Imaging
Immunoproliferative diseases
Immunosuppression
Infections
Infectious mononucleosis
Lymphadenopathy
Lymphocytes B
Lymphoma
Lymphoma - diagnostic imaging
Lymphoma - etiology
Lymphoma - virology
Medicine
Medicine & Public Health
Mononucleosis
Nasopharyngeal carcinoma
Neoplasms
Nuclear Medicine
Pathogenesis
Patients
Positron emission
Positron emission tomography
Positron Emission Tomography Computed Tomography - methods
Radiology
Review Article
Tomography
Tumors
Viruses
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Description
Summary:Epstein–Barr virus (EBV) is one of the most common viruses, infecting more than 90% of the adult population worldwide. EBV genome is detected in some lymphoid neoplasms. Not only their histopathological subtypes, but also their backgrounds and their clinical courses are variable. A number of B-cell lymphoproliferative disorders associated with the immunocompromised state are related to EBV infection. The incidences of these disorders have been increasing along with generalization of organ transplantations and use of immunosuppressive treatments. Furthermore, some EBV-positive lymphoma can also occur in immunocompetent patients. While evaluating patients with generalized lymphadenopathy of unknown cause by positron emission tomography/computed tomography with 2-deoxy-2-[ 18 F]fluoro- d -glucose (FDG-PET/CT), the possibility of lymphoid neoplasms should be considered in some patients, and a careful review of the background and previous history of the patients is necessary. In this review article, we describe the pathogenesis of EBV-related lymphoid neoplasms and then present FDG-PET/CT images of representative diseases. In addition, we also present a review of other EBV-related diseases, such as infectious mononucleosis and nasopharyngeal carcinoma.
ISSN:0914-7187
1864-6433
DOI:10.1007/s12149-017-1180-5