Intracortical signal processing of periodontal ligament sensations in rat

Highlights • The cortical mechanism underlying the signal processing of orofacial somatosense was studied using an in vivo imaging. • Stimulation to the periodontal ligament evokes the simultaneous activation of plural cortical regions. • Such evoked responses are observed in the insular oral region...

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Bibliographic Details
Published in:Neuroscience 2017-07, Vol.355, p.212-224
Main Authors: Minoda, Aoi, Mizoguchi, Naoko, Kobayashi, Masayuki, Suda, Naoto, Muramoto, Kazuyo
Format: Article
Language:English
Subjects:
Anesthetics, Local - pharmacology
Animals
Biotin - analogs & derivatives
Biotin - metabolism
Brain Mapping
Dextrans - metabolism
Electric Stimulation
insular cortex
Male
Mouth - innervation
Neural Pathways - diagnostic imaging
Neural Pathways - physiology
Neurology
optical imaging
Optical Imaging - methods
Periodontal Ligament - diagnostic imaging
Periodontal Ligament - drug effects
Periodontal Ligament - physiology
Rats
Rats, Sprague-Dawley
Sensation
somatosensory cortex
Somatosensory Cortex - diagnostic imaging
Somatosensory Cortex - physiology
Stilbamidines - metabolism
Tetrodotoxin - pharmacology
voltage-sensitive dye imaging
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Summary:Highlights • The cortical mechanism underlying the signal processing of orofacial somatosense was studied using an in vivo imaging. • Stimulation to the periodontal ligament evokes the simultaneous activation of plural cortical regions. • Such evoked responses are observed in the insular oral region as well as the primary and secondary somatosensory cortices. • The presence of a bi-directional connection among these cortices is demonstrated by physiological and morphological studies. • The intracortical interactions imply crucial neural mechanism for comprehensive recognition of intraoral somatosense.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2017.04.045