Human neural stem/progenitor cells derived from the olfactory epithelium express the TrkB receptor and migrate in response to BDNF

Highlights • BDNF modulates migration of hNS/PCs-OE. • TrkB is involved in BDNF-induced hNS/PCs-OE migration. • BDNF modifies vinculin focal adhesions of differentiated hNS/PCs-OE.

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Bibliographic Details
Published in:Neuroscience 2017-07, Vol.355, p.84-100
Main Authors: Ortiz-López, Leonardo, González-Olvera, Jorge Julio, Vega-Rivera, Nelly Maritza, García-Anaya, Maria, Carapia-Hernández, Ana Karen, César Velázquez-Escobar, Julio, Ramírez-Rodríguez, Gerardo Bernabé
Format: Article
Language:English
Subjects:
adult neurogenesis
BDNF
Brain-Derived Neurotrophic Factor - pharmacology
Carbazoles - pharmacology
Cell Adhesion - drug effects
Cell Differentiation - drug effects
Cell Movement - drug effects
Cell Proliferation - drug effects
Cells, Cultured
Colchicine - pharmacology
Enzyme Inhibitors - pharmacology
Histones - metabolism
Humans
Indole Alkaloids - pharmacology
Ki-67 Antigen - metabolism
migration
Nerve Tissue Proteins - metabolism
Neural Stem Cells - drug effects
neural stem/progenitor cells
Neurology
olfactory epithelium
Olfactory Mucosa - cytology
Receptor, trkB - metabolism
Time Factors
Tubulin - metabolism
vinculin
Vinculin - metabolism
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Summary:Highlights • BDNF modulates migration of hNS/PCs-OE. • TrkB is involved in BDNF-induced hNS/PCs-OE migration. • BDNF modifies vinculin focal adhesions of differentiated hNS/PCs-OE.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2017.04.047