MR Imaging for accurate Prediction of Outcome after Perinatal Arterial Ischemic Stroke: Sooner not Necessarily Better

Abstract Two full-term infants with perinatal arterial ischemic stroke (PAIS), with cerebral sinovenous thrombosis of the superior sagittal sinus in one of them, are reported. Diffusion weighted imaging (DWI)-MRI, performed within 24 hours following onset of seizures and repeated 48 hours later, cle...

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Bibliographic Details
Published in:European journal of paediatric neurology 2017-07, Vol.21 (4), p.666-670
Main Authors: Wagenaar, Nienke, MD, van der Aa, Niek E., MD PhD, Groenendaal, Floris, MD PhD, Benders, Manon J.N.L., MD PhD, de Vries, Linda S., MD PhD
Format: Article
Language:English
Subjects:
Corticospinal tract
Diffusion Magnetic Resonance Imaging - methods
Female
Humans
Infant
Male
Middle Aged
MRI
Neonate
Neurology
PAIS
Pediatrics
Pyramidal Tracts - diagnostic imaging
Pyramidal Tracts - pathology
Stroke
Stroke - diagnostic imaging
Stroke - pathology
Time Factors
Wallerian
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Summary:Abstract Two full-term infants with perinatal arterial ischemic stroke (PAIS), with cerebral sinovenous thrombosis of the superior sagittal sinus in one of them, are reported. Diffusion weighted imaging (DWI)-MRI, performed within 24 hours following onset of seizures and repeated 48 hours later, clearly showed restricted diffusion within the middle cerebral artery territory on both MRIs, but clear patterns of signal intensity changes in the descending corticospinal tracts on the second MRI only. Since involvement of these structures is essential for prediction of motor outcome, we may need to reconsider optimal timing of MR imaging for prediction of neurodevelopmental outcome after PAIS.
ISSN:1090-3798
1532-2130
DOI:10.1016/j.ejpn.2017.04.002