Comparative prognostic value of postprocedural creatine kinase myocardial band and high‐sensitivity troponin T in patients with non‐ST‐segment elevation myocardial infarction undergoing percutaneous coronary intervention

• Published in: Catheterization and cardiovascular interventions 2018-02, Vol.91 (2), p.215-223
• Main Authors: Ndrepepa, Gjin, Colleran, Roisin, Braun, Siegmund, Xhepa, Erion, Hieber, Julia, Cassese, Salvatore, Fusaro, Massimiliano, Kufner, Sebastian, Laugwitz, Karl‐Ludwig, Schunkert, Heribert, Kastrati, Adnan
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Angioplasty; biomarkers; Biomarkers - blood; Calcium-binding protein; Creatine; Creatine kinase; Creatine Kinase, MB Form - blood; Electrocardiography; Fatalities; Female; Heart attacks; Heart diseases; Humans; Male; Median (statistics); Middle Aged; Mortality; Myocardial infarction; Non-ST Elevated Myocardial Infarction - blood; Non-ST Elevated Myocardial Infarction - diagnosis; Non-ST Elevated Myocardial Infarction - mortality; Non-ST Elevated Myocardial Infarction - surgery; non‐ST‐segment elevation myocardial infarction; percutaneous coronary intervention; Percutaneous Coronary Intervention - adverse effects; Percutaneous Coronary Intervention - mortality; Predictive Value of Tests; Retrospective Studies; Risk Factors; Sensitivity; Time Factors; Treatment Outcome; Troponin; Troponin T; Troponin T - blood
• ISSN: 1522-1946; 1522-726X
• DOI: 10.1002/ccd.27105

Objectives We aimed to assess the prognostic value of postprocedural creatine kinase myocardial band (CK‐MB) and cardiac troponin (cTn) in patients with non‐ST‐segment elevation myocardial infarction (NSTEMI). Background: Whether postprocedural CK‐MB or cTn is a better biomarker to stratify the risk after percutaneous coronary intervention (PCI) remains unknown. Methods: This study included 2,077 patients with NSTEMI undergoing early PCI. Peak postprocedural values of CK‐MB and high‐sensitivity cTn T (hs‐cTnT) were analyzed. The primary outcome was 3‐year mortality. Results: The median values of peak postprocedural CK‐MB and hs‐cTnT were 18.3 U L−1 and 0.140 µg L−1, respectively. Overall, 211 patients died during follow‐up. There were 129 deaths in patients with CK‐MB >the median value and 82 deaths in those with CK‐MB ≤the median value (Kaplan–Meier estimates of 3‐year mortality, 18.9% and 14.0%, respectively; hazard ratio [HR] = 1.52, 95% confidence interval [CI] 1.16–2.01; P the median value and 77 deaths in patients with hs‐cTnT ≤the median value (Kaplan–Meier estimates of 3‐year mortality, 19.9% and 13.2%, respectively; HR = 1.90 [1.44–2.52]; P