Hydrogen peroxide induces cell proliferation and apoptosis in pulp of rats after dental bleaching in vivo: Effects of the dental bleaching in pulp

This study provides an in vivo evaluation of the inflammatory response, levels of cell proliferation and apoptosis, and the presence of necrosis after dental bleaching with two concentrations of hydrogen peroxide (H O ). Wistar rats were divided into Control (placebo gel), BLUE (20% H O , 1×50min),...

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Bibliographic Details
Published in:Archives of oral biology 2017-09, Vol.81, p.103-109
Main Authors: Benetti, Francine, Gomes-Filho, João Eduardo, Ferreira, Luciana Louzada, Ervolino, Edilson, Briso, André Luiz Fraga, Sivieri-Araújo, Gustavo, Dezan-Júnior, Eloi, Cintra, Luciano Tavares Angelo
Format: Article
Language:English
Subjects:
Animals
Apoptosis - drug effects
Cell Proliferation - drug effects
Dental Pulp - cytology
Dental Pulp - drug effects
Dental Pulp Necrosis - chemically induced
Dentistry
Hydrogen Peroxide - toxicity
Immunohistochemistry
Male
Rats
Rats, Wistar
Tooth Bleaching Agents - toxicity
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Summary:This study provides an in vivo evaluation of the inflammatory response, levels of cell proliferation and apoptosis, and the presence of necrosis after dental bleaching with two concentrations of hydrogen peroxide (H O ). Wistar rats were divided into Control (placebo gel), BLUE (20% H O , 1×50min), and MAXX (35% H O , 3×15min) groups. At 2 and 30days, the rats were killed (n=10). The jaws were processed for histology analysis and PCNA and Caspase-3-cleaved immunohistochemistry, and data were submitted to the Mann-Whitney or ANOVA test (P
ISSN:1879-1506
DOI:10.1016/j.archoralbio.2017.04.013