MAIT cells and MR1-antigen recognition

Highlights • MR1 presents vitamin B precursors and metabolites to MAIT cells. • The MR1-restricted T cell repertoire is diverse. • MAIT TCR heterogeneity can impact on MR1-antigen responsiveness. • MR1 presents drugs and drug-like molecules.

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Bibliographic Details
Published in:Current opinion in immunology 2017-06, Vol.46, p.66-74
Main Authors: Keller, Andrew N, Corbett, Alexandra J, Wubben, Jacinta M, McCluskey, James, Rossjohn, Jamie
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antigen Presentation - immunology
Bacterial Infections
Disease Susceptibility - immunology
Disease Susceptibility - metabolism
Histocompatibility Antigens Class I - chemistry
Histocompatibility Antigens Class I - immunology
Histocompatibility Antigens Class I - metabolism
Humans
Immunity, Innate
Minor Histocompatibility Antigens - chemistry
Minor Histocompatibility Antigens - immunology
Minor Histocompatibility Antigens - metabolism
Mucosal-Associated Invariant T Cells - immunology
Mucosal-Associated Invariant T Cells - metabolism
Protein Binding
Quantitative Structure-Activity Relationship
Receptors, Antigen, T-Cell - chemistry
Receptors, Antigen, T-Cell - metabolism
T-Lymphocyte Subsets - immunology
T-Lymphocyte Subsets - metabolism
Vitamin B Complex - immunology
Vitamin B Complex - metabolism
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Description
Summary:Highlights • MR1 presents vitamin B precursors and metabolites to MAIT cells. • The MR1-restricted T cell repertoire is diverse. • MAIT TCR heterogeneity can impact on MR1-antigen responsiveness. • MR1 presents drugs and drug-like molecules.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2017.04.002