Inflammatory cytokines and oxidative stress biomarkers in irritable bowel syndrome: Association with digestive symptoms and quality of life

A growing body of evidence suggests a possible role for low-grade inflammation in the pathogenesis of irritable bowel syndrome (IBS). The objectives of this study were to measure serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-17, interleukin (IL)-10, malondialdehyde (MDA) and total...

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Bibliographic Details
Published in:Cytokine (Philadelphia, Pa.) Pa.), 2017-05, Vol.93, p.34-43
Main Authors: Choghakhori, Razieh, Abbasnezhad, Amir, Hasanvand, Amin, Amani, Reza
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Cytokines - blood
Digestive symptoms
Female
Humans
Inflammation Mediators - blood
Inflammatory cytokines
Irritable bowel syndrome
Irritable Bowel Syndrome - blood
Irritable Bowel Syndrome - therapy
Male
Middle Aged
Oxidative stress biomarkers
Quality of Life
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Summary:A growing body of evidence suggests a possible role for low-grade inflammation in the pathogenesis of irritable bowel syndrome (IBS). The objectives of this study were to measure serum levels of tumor necrosis factor (TNF)-α, interleukin (IL)-17, interleukin (IL)-10, malondialdehyde (MDA) and total antioxidant capacity (TAC) in IBS patients and healthy controls (HCs), and to evaluate possible correlations of such markers with gastrointestinal (GI) symptoms and quality of life (QoL). Ninety Rome III positive IBS patients and 90 sex and age matched HCs were recruited. GI symptoms, IBS-QoL, IBS severity score system (IBSSS), and the serum levels of inflammatory cytokines and oxidative stress biomarkers were evaluated. In IBS patients, TNFα, IL-17 and MDA cytokines were significantly (P
ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2017.05.005