Role of the low-selective organic anion transport in regulation of osmotic balance of renal collecting duct principal cells under hypo-osmotic conditions

In the course of adaptation of the rat kidney collecting duct cells to hypo-osmotic medium, the organic anion transporter inhibitor probenecid reduced significantly the regulatory cell volume decrease in response to a hypotonic shock. Both probenecid and hypotonic shock delayed significantly the ent...

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Bibliographic Details
Published in:Doklady. Biological sciences 2017-03, Vol.473 (1), p.43-45
Main Authors: Baturina, G. S., Katkova, L. E., Solenov, E. I., Ivanova, L. N.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Calcein
Cell size
Cell Size - drug effects
Collecting duct
Evolutionary Biology
Fluorescent indicators
Hydrogen-Ion Concentration
Kidney - metabolism
Kidney - physiology
Kidney Tubules, Collecting - metabolism
Kidney Tubules, Collecting - physiology
Life Sciences
Organic Anion Transporters, Sodium-Independent - metabolism
Osmotic Pressure - physiology
Physiology
Plant Sciences
Probenecid - pharmacology
Rats
Rodents
Sodium
Water-Electrolyte Balance - physiology
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Summary:In the course of adaptation of the rat kidney collecting duct cells to hypo-osmotic medium, the organic anion transporter inhibitor probenecid reduced significantly the regulatory cell volume decrease in response to a hypotonic shock. Both probenecid and hypotonic shock delayed significantly the entry into a cell of the fluorescent dye calcein, which exists as anion at neutral pH. Thus, the organic osmolyte transport plays an important role in the regulatory decrease of the principal cell volume under the hypo-osmotic conditions.
ISSN:0012-4966
1608-3105
DOI:10.1134/S0012496617020090